Detalles de la búsqueda
1.
A new class of pentapeptide KISS1 receptor agonists with hypothalamic-pituitary-gonadal axis activation.
Bioorg Med Chem Lett
; 29(4): 654-658, 2019 02 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-30598349
2.
Growth Inhibition by Testosterone in an Androgen Receptor Splice Variant-Driven Prostate Cancer Model.
Prostate
; 76(16): 1536-1545, 2016 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-27473672
3.
Synthesis and biological evaluation of novel selective androgen receptor modulators (SARMs). Part I.
Bioorg Med Chem
; 23(10): 2568-78, 2015 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-25862209
4.
The effects of chronic subcutaneous administration of an investigational kisspeptin analog, TAK-683, on gonadotropin-releasing hormone pulse generator activity in goats.
Neuroendocrinology
; 100(2-3): 250-64, 2014.
Artículo
en Inglés
| MEDLINE | ID: mdl-25428554
5.
Differential effects of continuous exposure to the investigational metastin/kisspeptin analog TAK-683 on pulsatile and surge mode secretion of luteinizing hormone in ovariectomized goats.
J Reprod Dev
; 59(6): 563-8, 2013 Dec 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-24047956
6.
Design, synthesis, and biological evaluation of 4-phenylpyrrole derivatives as novel androgen receptor antagonists.
Bioorg Med Chem
; 20(1): 422-34, 2012 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-22094279
7.
17,20-lyase inhibitors. Part 4: design, synthesis and structure-activity relationships of naphthylmethylimidazole derivatives as novel 17,20-lyase inhibitors.
Bioorg Med Chem
; 19(5): 1751-70, 2011 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21316976
8.
17,20-Lyase inhibitors. Part 3: Design, synthesis, and structure-activity relationships of biphenylylmethylimidazole derivatives as novel 17,20-lyase inhibitors.
Bioorg Med Chem
; 19(7): 2428-42, 2011 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21429754
9.
Discovery of orteronel (TAK-700), a naphthylmethylimidazole derivative, as a highly selective 17,20-lyase inhibitor with potential utility in the treatment of prostate cancer.
Bioorg Med Chem
; 19(21): 6383-99, 2011 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21978946
10.
2-acylamino-4,6-diphenylpyridine derivatives as novel GPR54 antagonists with good brain exposure and in vivo efficacy for plasma LH level in male rats.
Bioorg Med Chem
; 18(14): 5157-71, 2010 Jul 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-20580563
11.
A novel androgen-dependent prostate cancer xenograft model derived from skin metastasis of a Japanese patient.
Prostate
; 69(15): 1660-7, 2009 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19644954
12.
Evaluation of pharmacokinetics/pharmacodynamics and efficacy of one-month depots of TAK-448 and TAK-683, investigational kisspeptin analogs, in male rats and an androgen-dependent prostate cancer model.
Eur J Pharmacol
; 822: 138-146, 2018 Mar 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-29355559
13.
Enhanced androgen receptor signaling correlates with the androgen-refractory growth in a newly established MDA PCa 2b-hr human prostate cancer cell subline.
Cancer Res
; 63(17): 5622-8, 2003 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-14500404
14.
Novel mutations of androgen receptor: a possible mechanism of bicalutamide withdrawal syndrome.
Cancer Res
; 63(1): 149-53, 2003 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-12517791
15.
Design and Synthesis of an Investigational Nonapeptide KISS1 Receptor (KISS1R) Agonist, Ac-d-Tyr-Hydroxyproline (Hyp)-Asn-Thr-Phe-azaGly-Leu-Arg(Me)-Trp-NH2 (TAK-448), with Highly Potent Testosterone-Suppressive Activity and Excellent Water Solubility.
J Med Chem
; 59(19): 8804-8811, 2016 10 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-27589480
16.
Selective androgen receptor modulator activity of a steroidal antiandrogen TSAA-291 and its cofactor recruitment profile.
Eur J Pharmacol
; 765: 322-31, 2015 Oct 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26335395
17.
Suppression of a pituitary-ovarian axis by chronic oral administration of a novel nonpeptide gonadotropin-releasing hormone antagonist, TAK-013, in cynomolgus monkeys.
J Clin Endocrinol Metab
; 88(4): 1697-704, 2003 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-12679460
18.
Novel benzimidazole derivatives selectively inhibit endothelial cell growth and suppress angiogenesis in vitro and in vivo.
Cancer Lett
; 183(1): 53-60, 2002 Sep 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-12049814
19.
Suppression of the hypothalamic-pituitary-gonadal axis by TAK-385 (relugolix), a novel, investigational, orally active, small molecule gonadotropin-releasing hormone (GnRH) antagonist: studies in human GnRH receptor knock-in mice.
Eur J Pharmacol
; 723: 167-74, 2014 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-24333551
20.
Physicochemically and pharmacokinetically stable nonapeptide KISS1 receptor agonists with highly potent testosterone-suppressive activity.
J Med Chem
; 57(14): 6105-15, 2014 Jul 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-24918545