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1.
From structure to clinic: Design of a muscarinic M1 receptor agonist with potential to treatment of Alzheimer's disease.
Cell
; 184(24): 5886-5901.e22, 2021 11 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-34822784
2.
Safety, pharmacokinetics and pharmacodynamics of HTL0009936, a selective muscarinic M1 -acetylcholine receptor agonist: A randomized cross-over trial.
Br J Clin Pharmacol
; 87(11): 4439-4449, 2021 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-33891333
3.
First-in-man study to investigate safety, pharmacokinetics and exploratory pharmacodynamics of HTL0018318, a novel M1 -receptor partial agonist for the treatment of dementias.
Br J Clin Pharmacol
; 87(7): 2945-2955, 2021 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-33351971
4.
Safety and Pharmacokinetics of HTL0018318, a Novel M1 Receptor Agonist, Given in Combination with Donepezil at Steady State: A Randomized Trial in Healthy Elderly Subjects.
Drugs R D
; 21(3): 295-304, 2021 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-34164794
5.
Safety, pharmacokinetics and exploratory pro-cognitive effects of HTL0018318, a selective M1 receptor agonist, in healthy younger adult and elderly subjects: a multiple ascending dose study.
Alzheimers Res Ther
; 13(1): 87, 2021 04 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-33883008
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