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1.
TBK1 phosphorylates mutant Huntingtin and suppresses its aggregation and toxicity in Huntington's disease models.
EMBO J
; 39(17): e104671, 2020 09 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32757223
2.
Ultrasensitive quantitative measurement of huntingtin phosphorylation at residue S13.
Biochem Biophys Res Commun
; 521(3): 549-554, 2020 01 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-31677786
3.
Phosphorylation of huntingtin at residue T3 is decreased in Huntington's disease and modulates mutant huntingtin protein conformation.
Proc Natl Acad Sci U S A
; 114(50): E10809-E10818, 2017 12 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-29162692
4.
Recombinant Adeno Associated Viral (AAV) vector type 9 delivery of Ex1-Q138-mutant huntingtin in the rat striatum as a short-time model for in vivo studies in drug discovery.
Neurobiol Dis
; 86: 41-51, 2016 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-26626080
5.
Conformational modulation mediated by polyglutamine expansion in CAG repeat expansion disease-associated proteins.
Biochem Biophys Res Commun
; 478(2): 949-55, 2016 09 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-27520369
6.
Detection of huntingtin exon 1 phosphorylation by Phos-Tag SDS-PAGE: Predominant phosphorylation on threonine 3 and regulation by IKKß.
Biochem Biophys Res Commun
; 463(4): 1317-22, 2015 Aug 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-26106822
7.
Development of an ELISA assay for the quantification of soluble huntingtin in human blood cells.
BMC Biochem
; 14: 34, 2013 Nov 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-24274906
8.
IKBKB reduces huntingtin aggregation by phosphorylating serine 13 via a non-canonical IKK pathway.
Life Sci Alliance
; 6(10)2023 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-37553253
9.
Comparative Analysis of Total Alpha-Synuclein (αSYN) Immunoassays Reveals That They Do Not Capture the Diversity of Modified αSYN Proteoforms.
J Parkinsons Dis
; 12(5): 1449-1462, 2022.
Artículo
en Inglés
| MEDLINE | ID: mdl-35527570
10.
Cholesterol defect is marked across multiple rodent models of Huntington's disease and is manifest in astrocytes.
J Neurosci
; 30(32): 10844-50, 2010 Aug 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-20702713
11.
Striatal infusion of cholesterol promotes dose-dependent behavioral benefits and exerts disease-modifying effects in Huntington's disease mice.
EMBO Mol Med
; 12(10): e12519, 2020 10 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-32959531
12.
Phospho-S129 Alpha-Synuclein Is Present in Human Plasma but Not in Cerebrospinal Fluid as Determined by an Ultrasensitive Immunoassay.
Front Neurosci
; 13: 889, 2019.
Artículo
en Inglés
| MEDLINE | ID: mdl-31507364
13.
Inhibiting pathologically active ADAM10 rescues synaptic and cognitive decline in Huntington's disease.
J Clin Invest
; 129(6): 2390-2403, 2019 05 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-31063986
14.
Polyglutamine expansion affects huntingtin conformation in multiple Huntington's disease models.
Sci Rep
; 7(1): 5070, 2017 07 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-28698602
15.
Polyglutamine- and temperature-dependent conformational rigidity in mutant huntingtin revealed by immunoassays and circular dichroism spectroscopy.
PLoS One
; 9(12): e112262, 2014.
Artículo
en Inglés
| MEDLINE | ID: mdl-25464275
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