Detalles de la búsqueda
1.
Discovery of 4-alkylamino-7-aryl-3-cyanoquinoline LRRK2 kinase inhibitors.
Bioorg Med Chem Lett
; 23(7): 1974-7, 2013 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23453068
2.
Structure-based design of novel dihydroisoquinoline BACE-1 inhibitors that do not engage the catalytic aspartates.
Bioorg Med Chem Lett
; 23(7): 2181-6, 2013 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23465612
3.
Design and synthesis of thiophene dihydroisoquinolines as novel BACE1 inhibitors.
Bioorg Med Chem Lett
; 23(10): 3075-80, 2013 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23570791
4.
Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: prime side chromane-containing inhibitors.
Bioorg Med Chem Lett
; 23(16): 4674-9, 2013 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23856050
5.
Design and synthesis of highly selective, orally active Polo-like kinase-2 (Plk-2) inhibitors.
Bioorg Med Chem Lett
; 23(9): 2743-9, 2013 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23522834
6.
Highly selective c-Jun N-terminal kinase (JNK) 3 inhibitors with in vitro CNS-like pharmacokinetic properties II. Central core replacement.
Bioorg Med Chem Lett
; 21(12): 3726-9, 2011 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-21570836
7.
Design and synthesis of a novel, orally active, brain penetrant, tri-substituted thiophene based JNK inhibitor.
Bioorg Med Chem Lett
; 21(6): 1838-43, 2011 Mar 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-21316234
8.
Design and synthesis of brain penetrant selective JNK inhibitors with improved pharmacokinetic properties for the prevention of neurodegeneration.
Bioorg Med Chem Lett
; 21(18): 5521-7, 2011 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-21813278
9.
Highly selective c-Jun N-terminal kinase (JNK) 2 and 3 inhibitors with in vitro CNS-like pharmacokinetic properties prevent neurodegeneration.
Bioorg Med Chem Lett
; 21(1): 315-9, 2011 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21112785
10.
Design of an orally efficacious hydroxyethylamine (HEA) BACE-1 inhibitor in a preclinical animal model.
Bioorg Med Chem Lett
; 20(21): 6231-6, 2010 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20833041
11.
Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: structure-activity relationship of the aryl region.
Bioorg Med Chem Lett
; 20(20): 6034-9, 2010 Oct 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-20822903
12.
Improving the permeability of the hydroxyethylamine BACE-1 inhibitors: structure-activity relationship of P2' substituents.
Bioorg Med Chem Lett
; 20(16): 4789-94, 2010 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-20634069
13.
Design and synthesis of cell potent BACE-1 inhibitors: structure-activity relationship of P1' substituents.
Bioorg Med Chem Lett
; 19(22): 6386-91, 2009 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-19811916
14.
A selective small molecule inhibitor of c-Met kinase inhibits c-Met-dependent phenotypes in vitro and exhibits cytoreductive antitumor activity in vivo.
Cancer Res
; 63(21): 7345-55, 2003 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-14612533
15.
A widely applicable, high-throughput TR-FRET assay for the measurement of kinase autophosphorylation: VEGFR-2 as a prototype.
J Biomol Screen
; 8(4): 447-52, 2003 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-14567797
16.
Selective and brain-permeable polo-like kinase-2 (Plk-2) inhibitors that reduce α-synuclein phosphorylation in rat brain.
ChemMedChem
; 8(8): 1295-313, 2013 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-23794260
17.
Discovery of (R)-4-cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)phenylsulfonyl)-4,5-dihydro-1H-pyrazolo[4,3-c]quinoline (ELND006) and (R)-4-cyclopropyl-8-fluoro-5-(6-(trifluoromethyl)pyridin-3-ylsulfonyl)-4,5-dihydro-2H-pyrazolo[4,3-c]quinoline (ELND007): metabolically stable γ-secretase Inhibitors that selectively inhibit the production of amyloid-ß over Notch.
J Med Chem
; 56(13): 5261-74, 2013 Jul 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-23713656
18.
Amyloid precursor protein selective gamma-secretase inhibitors for treatment of Alzheimer's disease.
Alzheimers Res Ther
; 2(6): 36, 2010 Dec 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-21190552
19.
Pharmacological, pharmacokinetic, and primate analgesic efficacy profile of the novel bradykinin B1 Receptor antagonist ELN441958.
J Pharmacol Exp Ther
; 322(2): 619-30, 2007 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-17470643
Resultados
1 -
19
de 19
1
Próxima >
>>