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1.

Î³-Secretase: a horseshoe structure brings good luck.

Wolfe, Michael S; Selkoe, Dennis J.

Cell ; 158(2): 247-249, 2014 Jul 17.

Artículo en Inglés | MEDLINE | ID: mdl-25036627

2.

Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment.

Fanning, Saranna; Haque, Aftabul; Imberdis, Thibaut; Baru, Valeriya; Barrasa, M Inmaculada; Nuber, Silke; Termine, Daniel; Ramalingam, Nagendran; Ho, Gary P H; Noble, Tallie; Sandoe, Jackson; Lou, Yali; Landgraf, Dirk; Freyzon, Yelena; Newby, Gregory; Soldner, Frank; Terry-Kantor, Elizabeth; Kim, Tae-Eun; Hofbauer, Harald F; Becuwe, Michel; Jaenisch, Rudolf; Pincus, David; Clish, Clary B; Walther, Tobias C; Farese, Robert V; Srinivasan, Supriya; Welte, Michael A; Kohlwein, Sepp D; Dettmer, Ulf; Lindquist, Susan; Selkoe, Dennis.

Mol Cell ; 73(5): 1001-1014.e8, 2019 03 07.

Artículo en Inglés | MEDLINE | ID: mdl-30527540

3.

PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motility.

Wang, Xinnan; Winter, Dominic; Ashrafi, Ghazaleh; Schlehe, Julia; Wong, Yao Liang; Selkoe, Dennis; Rice, Sarah; Steen, Judith; LaVoie, Matthew J; Schwarz, Thomas L.

Cell ; 147(4): 893-906, 2011 Nov 11.

Artículo en Inglés | MEDLINE | ID: mdl-22078885

4.

If amyloid drives Alzheimer disease, why have anti-amyloid therapies not yet slowed cognitive decline?

Haass, Christian; Selkoe, Dennis.

PLoS Biol ; 20(7): e3001694, 2022 07.

Artículo en Inglés | MEDLINE | ID: mdl-35862308

5.

Dynamic reversibility of α-synuclein serine-129 phosphorylation is impaired in synucleinopathy models.

Ramalingam, Nagendran; Brontesi, Lisa; Jin, Shan-Xue; Selkoe, Dennis J; Dettmer, Ulf.

EMBO Rep ; 24(12): e57145, 2023 Dec 06.

Artículo en Inglés | MEDLINE | ID: mdl-37870370

6.

Giving Alzheimer's the old one-two.

Wolfe, Michael S; Selkoe, Dennis J.

Cell ; 142(2): 194-6, 2010 Jul 23.

Artículo en Inglés | MEDLINE | ID: mdl-20655461

7.

The Parkinson-Associated Toxin Paraquat Shifts Physiological α-Synuclein Tetramers toward Monomers That Can Be Calpain-Truncated and Form Oligomers.

Nuber, Silke; Selkoe, Dennis J.

Am J Pathol ; 193(5): 520-531, 2023 05.

Artículo en Inglés | MEDLINE | ID: mdl-36773784

8.

Activation of ß₂-adrenergic receptors prevents AD-type synaptotoxicity via epigenetic mechanisms.

Jin, Ming; Wei, Zhiyun; Ramalingam, Nagendran; Xiao, Meng; Xu, Anqi; Yu, Xiaohan; Song, Qingyang; Liu, Wen; Zhao, Jianhua; Zhang, Dainan; Selkoe, Dennis J; Li, Shaomin.

Mol Psychiatry ; 28(11): 4877-4888, 2023 Nov.

Artículo en Inglés | MEDLINE | ID: mdl-37365243

9.

Wild-type GBA1 increases the α-synuclein tetramer-monomer ratio, reduces lipid-rich aggregates, and attenuates motor and cognitive deficits in mice.

Glajch, Kelly E; Moors, Tim E; Chen, Yi; Bechade, Pascal A; Nam, Alice Y; Rajsombath, Molly M; McCaffery, Thomas D; Dettmer, Ulf; Weihofen, Andreas; Hirst, Warren D; Selkoe, Dennis J; Nuber, Silke.

Proc Natl Acad Sci U S A ; 118(31)2021 08 03.

Artículo en Inglés | MEDLINE | ID: mdl-34326260

10.

Uncovering elevated tau TPP motif phosphorylation in the brain of Alzheimer's disease patients.

Bellier, Jean-Pierre; Cai, Yuqi; Alam, Sarah M; Wiederhold, Thorsten; Aiello, Arica; Vogelgsang, Jonathan S; Berretta, Sabina; Chhatwal, Jasmeer P; Selkoe, Dennis J; Liu, Lei.

Alzheimers Dement ; 20(3): 1573-1585, 2024 Mar.

Artículo en Inglés | MEDLINE | ID: mdl-38041855

11.

Pathogenic Mechanisms of Cytosolic and Membrane-Enriched α-Synuclein Converge on Fatty Acid Homeostasis.

Tripathi, Arati; Alnakhala, Heba; Terry-Kantor, Elizabeth; Newman, Andrew; Liu, Lei; Imberdis, Thibaut; Fanning, Saranna; Nuber, Silke; Ramalingam, Nagendran; Selkoe, Dennis; Dettmer, Ulf.

J Neurosci ; 42(10): 2116-2130, 2022 03 09.

Artículo en Inglés | MEDLINE | ID: mdl-35086904

12.

Excess membrane binding of monomeric alpha-, beta- and gamma-synuclein is invariably associated with inclusion formation and toxicity.

Kim, Tae-Eun; Newman, Andrew J; Imberdis, Thibaut; Brontesi, Lisa; Tripathi, Arati; Ramalingam, Nagendran; Fanning, Saranna; Selkoe, Dennis; Dettmer, Ulf.

Hum Mol Genet ; 30(23): 2332-2346, 2021 11 16.

Artículo en Inglés | MEDLINE | ID: mdl-34254125

13.

A calcium-sensitive antibody isolates soluble amyloid-ß aggregates and fibrils from Alzheimer's disease brain.

Stern, Andrew M; Liu, Lei; Jin, Shanxue; Liu, Wen; Meunier, Angela L; Ericsson, Maria; Miller, Michael B; Batson, Megan; Sun, Tingwan; Kathuria, Sagar; Reczek, David; Pradier, Laurent; Selkoe, Dennis J.

Brain ; 145(7): 2528-2540, 2022 07 29.

Artículo en Inglés | MEDLINE | ID: mdl-35084489

14.

SnapShot: pathobiology of Alzheimer's disease.

Selkoe, Dennis J.

Cell ; 154(2): 468-468.e1, 2013 Jul 18.

Artículo en Inglés | MEDLINE | ID: mdl-23870132

15.

Identification of the Aß37/42 peptide ratio in CSF as an improved Aß biomarker for Alzheimer's disease.

Liu, Lei; Lauro, Bianca M; He, Amy; Lee, Hyo; Bhattarai, Sanjay; Wolfe, Michael S; Bennett, David A; Karch, Celeste M; Young-Pearse, Tracy; Selkoe, Dennis J.

Alzheimers Dement ; 19(1): 79-96, 2023 01.

Artículo en Inglés | MEDLINE | ID: mdl-35278341

16.

Plasma NT1-tau and Aß₄₂ correlate with age and cognitive function in two large Down syndrome cohorts.

Stern, Andrew M; Van Pelt, Kathryn L; Liu, Lei; Anderson, Amirah K; Ostaszewski, Beth; Mapstone, Mark; O'Bryant, Sid; Petersen, Melissa E; Christian, Bradley T; Handen, Benjamin L; Selkoe, Dennis J; Schmitt, Frederick; Head, Elizabeth.

Alzheimers Dement ; 19(12): 5755-5764, 2023 Dec.

Artículo en Inglés | MEDLINE | ID: mdl-37438872

17.

Hydrophilic loop 1 of Presenilin-1 and the APP GxxxG transmembrane motif regulate Î³-secretase function in generating Alzheimer-causing Aß peptides.

Liu, Lei; Lauro, Bianca M; Wolfe, Michael S; Selkoe, Dennis J.

J Biol Chem ; 296: 100393, 2021.

Artículo en Inglés | MEDLINE | ID: mdl-33571524

18.

Aß oligomers from human brain impair mossy fiber LTP in CA3 of hippocampus, but activating cAMP-PKA and cGMP-PKG prevents this.

Jin, Shan-Xue; Liu, Lei; Li, Shaomin; Meunier, Angela L; Selkoe, Dennis J.

Neurobiol Dis ; 172: 105816, 2022 10 01.

Artículo en Inglés | MEDLINE | ID: mdl-35820646

19.

Generation and application of semi-synthetic p-Tau181 calibrator for immunoassay calibration.

Liu, Lei; Cai, Yuqi; Lauro, Bianca M; Meunier, Angela L; Chhatwal, Jasmeer; Selkoe, Dennis J.

Biochem Biophys Res Commun ; 611: 85-90, 2022 06 30.

Artículo en Inglés | MEDLINE | ID: mdl-35483223

20.

A Stearoyl-Coenzyme A Desaturase Inhibitor Prevents Multiple Parkinson Disease Phenotypes in α-Synuclein Mice.

Nuber, Silke; Nam, Alice Y; Rajsombath, Molly M; Cirka, Haley; Hronowski, Xiaoping; Wang, Junmin; Hodgetts, Kevin; Kalinichenko, Liubov S; Müller, Christian P; Lambrecht, Vera; Winkler, Jürgen; Weihofen, Andreas; Imberdis, Thibaut; Dettmer, Ulf; Fanning, Saranna; Selkoe, Dennis J.

Ann Neurol ; 89(1): 74-90, 2021 01.

Artículo en Inglés | MEDLINE | ID: mdl-32996158

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