Detalles de la búsqueda
1.
Defining the mechanism of galectin-3-mediated TGF-ß1 activation and its role in lung fibrosis.
J Biol Chem
; 300(6): 107300, 2024 Apr 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-38641066
2.
An Inhaled Galectin-3 Inhibitor in COVID-19 Pneumonitis: A Phase Ib/IIa Randomized Controlled Clinical Trial (DEFINE).
Am J Respir Crit Care Med
; 207(2): 138-149, 2023 01 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-35972987
3.
Target inhibition of galectin-3 by inhaled TD139 in patients with idiopathic pulmonary fibrosis.
Eur Respir J
; 57(5)2021 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-33214209
4.
Downregulation of the αvß6 Integrin via RGD Engagement Is Affinity and Time Dependent.
J Pharmacol Exp Ther
; 376(2): 273-280, 2021 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-33318076
5.
A positron emission tomography imaging study to confirm target engagement in the lungs of patients with idiopathic pulmonary fibrosis following a single dose of a novel inhaled αvß6 integrin inhibitor.
Respir Res
; 21(1): 75, 2020 Mar 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-32216814
6.
Preclinical evaluation of [18F]FB-A20FMDV2 as a selective marker for measuring αVß6 integrin occupancy using positron emission tomography in rodent lung.
Eur J Nucl Med Mol Imaging
; 47(4): 958-966, 2020 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-31897589
7.
Safety, tolerability and pharmacokinetics of GSK3008348, a novel integrin αvß6 inhibitor, in healthy participants.
Eur J Clin Pharmacol
; 74(6): 701-709, 2018 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-29532104
8.
An αv-RGD Integrin Inhibitor Toolbox: Drug Discovery Insight, Challenges and Opportunities.
Angew Chem Int Ed Engl
; 57(13): 3298-3321, 2018 03 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-28944552
9.
Identification of selective 8-(piperidin-4-yloxy)quinoline sulfone and sulfonamide histamine H1 receptor antagonists for use in allergic rhinitis.
Bioorg Med Chem Lett
; 27(21): 4914-4919, 2017 11 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28958623
10.
The discovery of quinoline based single-ligand human H1 and H3 receptor antagonists.
Bioorg Med Chem Lett
; 26(24): 5855-5859, 2016 12 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27866818
11.
Pharmacological Characterization of the αvß6 Integrin Binding and Internalization Kinetics of the Foot-and-Mouth Disease Virus Derived Peptide A20FMDV2.
Pharmacology
; 97(3-4): 114-25, 2016.
Artículo
en Inglés
| MEDLINE | ID: mdl-26734728
12.
Discovery of the Selective and Orally Available Galectin-1 Inhibitor GB1908 as a Potential Treatment for Lung Cancer.
J Med Chem
; 67(11): 9374-9388, 2024 Jun 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-38804039
13.
In vitro pharmacological characterization of vilanterol, a novel long-acting ß2-adrenoceptor agonist with 24-hour duration of action.
J Pharmacol Exp Ther
; 344(1): 218-30, 2013 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-23131596
14.
Pharmacological characterization of GSK573719 (umeclidinium): a novel, long-acting, inhaled antagonist of the muscarinic cholinergic receptors for treatment of pulmonary diseases.
J Pharmacol Exp Ther
; 345(2): 260-70, 2013 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-23435542
15.
Galectin-3: therapeutic targeting in liver disease.
Expert Opin Ther Targets
; 27(9): 779-791, 2023.
Artículo
en Inglés
| MEDLINE | ID: mdl-37705214
16.
Discovery of Selective and Orally Available Galectin-1 Inhibitors.
J Med Chem
; 66(24): 16980-16990, 2023 12 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-38059452
17.
Resistance to anti-PD-1/anti-PD-L1: galectin-3 inhibition with GB1211 reverses galectin-3-induced blockade of pembrolizumab and atezolizumab binding to PD-1/PD-L1.
Front Immunol
; 14: 1250559, 2023.
Artículo
en Inglés
| MEDLINE | ID: mdl-37701441
18.
Safety and pharmacokinetics of GB1211, an oral galectin-3 inhibitor: a single- and multiple-dose first-in-human study in healthy participants.
Cancer Chemother Pharmacol
; 91(3): 267-280, 2023 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-36914828
19.
Evaluating the affinity and kinetics of small molecule glycomimetics for human and mouse galectin-3 using surface plasmon resonance.
SLAS Discov
; 28(5): 233-239, 2023 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-36990319
20.
Lead optimisation of the N1 substituent of a novel series of indazole arylsulfonamides as CCR4 antagonists and identification of a candidate for clinical investigation.
Bioorg Med Chem Lett
; 22(8): 2730-3, 2012 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-22437117