Detalhe da pesquisa
1.
The Perturbed Free-Energy Landscape: Linking Ligand Binding to Biomolecular Folding.
Chembiochem
; 22(9): 1499-1516, 2021 05 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33351206
2.
Statistical mechanical prediction of ligand perturbation to RNA secondary structure and application to riboswitches.
J Comput Chem
; 41(16): 1521-1537, 2020 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32220073
3.
Basis for ligand discrimination between ON and OFF state riboswitch conformations: the case of the SAM-I riboswitch.
RNA
; 18(6): 1230-43, 2012 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-22543867
4.
The impact of a ligand binding on strand migration in the SAM-I riboswitch.
PLoS Comput Biol
; 9(5): e1003069, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-23704854
5.
A mechanism for S-adenosyl methionine assisted formation of a riboswitch conformation: a small molecule with a strong arm.
Nucleic Acids Res
; 37(19): 6528-39, 2009 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-19720737
6.
Protocol for efficient fluorescence 3' end-labeling of native noncoding RNA domains.
MethodsX
; 7: 101148, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-33299805
7.
Crystal structures of complexes between aminoglycosides and decoding A site oligonucleotides: role of the number of rings and positive charges in the specific binding leading to miscoding.
Nucleic Acids Res
; 33(17): 5677-90, 2005.
Artigo
em Inglês
| MEDLINE | ID: mdl-16214802
8.
Towards the discovery of drug-like RNA ligands?
Drug Discov Today
; 11(21-22): 1019-27, 2006 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-17055412
9.
Rational design of inhibitors of HIV-1 TAR RNA through the stabilisation of electrostatic "hot spots".
J Mol Biol
; 336(2): 343-56, 2004 Feb 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-14757049
10.
Structure-based drug design targeting an inactive RNA conformation: exploiting the flexibility of HIV-1 TAR RNA.
J Mol Biol
; 336(3): 625-38, 2004 Feb 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-15095977
11.
Structural basis for contrasting activities of ribosome binding thiazole antibiotics.
Chem Biol
; 10(8): 769-78, 2003 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-12954336
12.
Targeting the A site RNA of the Escherichia coli ribosomal 30 S subunit by 2'-O-methyl oligoribonucleotides: a quantitative equilibrium dialysis binding assay and differential effects of aminoglycoside antibiotics.
Biochem J
; 383(Pt 2): 201-8, 2004 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-15294017
13.
Linking aptamer-ligand binding and expression platform folding in riboswitches: prospects for mechanistic modeling and design.
Wiley Interdiscip Rev RNA
; 6(6): 631-50, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-26361734
14.
RNA as a drug target.
Prog Med Chem
; 39: 73-119, 2002.
Artigo
em Inglês
| MEDLINE | ID: mdl-12536671
15.
Conformational heterogeneity of the SAM-I riboswitch transcriptional ON state: a chaperone-like role for S-adenosyl methionine.
J Mol Biol
; 418(5): 331-49, 2012 May 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-22425639
16.
Strategies for the design of RNA-binding small molecules.
Future Med Chem
; 2(1): 93-119, 2010 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-21426048
17.
Design and implementation of an ribonucleic acid (RNA) directed fragment library.
J Med Chem
; 52(12): 3753-61, 2009 Jun 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-19445516
18.
Design and characterization of libraries of molecular fragments for use in NMR screening against protein targets.
J Chem Inf Comput Sci
; 44(6): 2157-66, 2004.
Artigo
em Inglês
| MEDLINE | ID: mdl-15554686
19.
A conserved RNA structure within the HCV IRES eIF3-binding site.
Nat Struct Biol
; 9(5): 375-80, 2002 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-11927954