Detalhe da pesquisa
1.
Intramolecular C-C Bond Formation Links Anthraquinone and Enediyne Scaffolds in Tiancimycin Biosynthesis.
J Am Chem Soc
; 144(44): 20452-20462, 2022 11 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36279548
2.
Discovery of ammosesters by mining the Streptomyces uncialis DCA2648 genome revealing new insight into ammosamide biosynthesis.
J Ind Microbiol Biotechnol
; 48(3-4)2021 Jun 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33982054
3.
Submerged fermentation of Streptomyces uncialis providing a biotechnology platform for uncialamycin biosynthesis, engineering, and production.
J Ind Microbiol Biotechnol
; 48(3-4)2021 Jun 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33739406
4.
Cryptic Sulfur Incorporation in Thioangucycline Biosynthesis.
Angew Chem Int Ed Engl
; 60(13): 7140-7147, 2021 03 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-33465268
5.
Challenges and opportunities for natural product discovery, production, and engineering in native producers versus heterologous hosts.
J Ind Microbiol Biotechnol
; 46(3-4): 433-444, 2019 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-30426283
6.
The Natural Products Discovery Center: Release of the First 8490 Sequenced Strains for Exploring Actinobacteria Biosynthetic Diversity.
bioRxiv
; 2024 May 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-38168313
7.
Neogrisemycin, a Trisulfide-Bridged Angucycline, Produced upon Expressing the Thioangucycline Biosynthetic Gene Cluster in Streptomyces albus J1074.
Org Lett
; 25(6): 961-965, 2023 02 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-36735280
8.
Application of a Biocatalytic Strategy for the Preparation of Tiancimycin-Based Antibody-Drug Conjugates Revealing Key Insights into Structure-Activity Relationships.
J Med Chem
; 66(2): 1562-1573, 2023 01 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-36599039
9.
Functional Characterization of Cytochrome P450 Hydroxylase YpmL in Yangpumicin A Biosynthesis and Its Application for Anthraquinone-Fused Enediyne Structural Diversification.
Org Lett
; 24(5): 1219-1223, 2022 02 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-35084871
10.
Challenges and Opportunities to Develop Enediyne Natural Products as Payloads for Antibody-Drug Conjugates.
Antib Ther
; 4(1): 1-15, 2021 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-33554043
11.
Cytochrome P450 Hydroxylase TnmL Catalyzing Sequential Hydroxylation with an Additional Proofreading Activity in Tiancimycin Biosynthesis.
ACS Chem Biol
; 16(7): 1172-1178, 2021 07 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-34138533
12.
Characterization of TnmH as an O-Methyltransferase Revealing Insights into Tiancimycin Biosynthesis and Enabling a Biocatalytic Strategy To Prepare Antibody-Tiancimycin Conjugates.
J Med Chem
; 63(15): 8432-8441, 2020 08 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-32658465
13.
Comparative Studies of the Biosynthetic Gene Clusters for Anthraquinone-Fused Enediynes Shedding Light into the Tailoring Steps of Tiancimycin Biosynthesis.
Org Lett
; 20(18): 5918-5921, 2018 09 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-30212211
14.
Genome Mining of Micromonospora yangpuensis DSM 45577 as a Producer of an Anthraquinone-Fused Enediyne.
Org Lett
; 19(22): 6192-6195, 2017 11 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-29086572