Detalhe da pesquisa
1.
Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response.
EMBO J
; 30(5): 894-905, 2011 Mar 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-21317875
2.
Targeting the Hsp90 chaperone: synthesis of novel resorcylic acid macrolactone inhibitors of Hsp90.
Chemistry
; 16(9): 2758-63, 2010 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20087915
3.
Inhibition of Hsp90 with resorcylic acid macrolactones: synthesis and binding studies.
Chemistry
; 16(34): 10366-72, 2010 Sep 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-20661961
4.
Design and synthesis of novel pyrimidine hydroxamic acid inhibitors of histone deacetylases.
Bioorg Med Chem Lett
; 20(22): 6657-60, 2010 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20884208
5.
Phase I pharmacokinetic and pharmacodynamic study of LAQ824, a hydroxamate histone deacetylase inhibitor with a heat shock protein-90 inhibitory profile, in patients with advanced solid tumors.
Clin Cancer Res
; 14(20): 6663-73, 2008 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18927309
6.
In vitro biological characterization of a novel, synthetic diaryl pyrazole resorcinol class of heat shock protein 90 inhibitors.
Cancer Res
; 67(5): 2206-16, 2007 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17332351
7.
Gene and protein expression profiling of human ovarian cancer cells treated with the heat shock protein 90 inhibitor 17-allylamino-17-demethoxygeldanamycin.
Cancer Res
; 67(7): 3239-53, 2007 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17409432
8.
4,5-diarylisoxazole Hsp90 chaperone inhibitors: potential therapeutic agents for the treatment of cancer.
J Med Chem
; 51(2): 196-218, 2008 Jan 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-18020435
9.
A duplexed phenotypic screen for the simultaneous detection of inhibitors of the molecular chaperone heat shock protein 90 and modulators of cellular acetylation.
Mol Cancer Ther
; 6(3): 1112-22, 2007 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-17363504
10.
Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues.
Mol Cancer Ther
; 6(4): 1198-211, 2007 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-17431102
11.
Application of meso scale technology for the measurement of phosphoproteins in human tumor xenografts.
Assay Drug Dev Technol
; 5(3): 391-401, 2007 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-17638539
12.
Identification of novel small molecule inhibitors of hypoxia-inducible factor-1 that differentially block hypoxia-inducible factor-1 activity and hypoxia-inducible factor-1alpha induction in response to hypoxic stress and growth factors.
Cancer Res
; 65(11): 4918-28, 2005 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-15930314
13.
Identification of novel keratinocyte differentiation modulating compounds by high-throughput screening.
J Biomol Screen
; 11(8): 977-84, 2006 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-17092913
14.
Identification of inhibitors of the kinase activity of oncogenic V600E BRAF in an enzyme cascade high-throughput screen.
J Biomol Screen
; 11(2): 145-54, 2006 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-16361694
15.
Identification of small-molecule inhibitors of protein kinase B (PKB/AKT) in an AlphaScreenTM high-throughput screen.
J Biomol Screen
; 11(7): 822-7, 2006 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-16902245
16.
Solid-phase immunoassays in mechanism-based drug discovery: their application in the development of inhibitors of the molecular chaperone heat-shock protein 90.
Assay Drug Dev Technol
; 3(3): 273-85, 2005 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-15971989
17.
Structure-activity relationships in purine-based inhibitor binding to HSP90 isoforms.
Chem Biol
; 11(6): 775-85, 2004 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-15217611
18.
Discovery of potent, orally bioavailable, small-molecule inhibitors of WNT signaling from a cell-based pathway screen.
J Med Chem
; 58(4): 1717-35, 2015 Feb 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-25680029
19.
High-throughput screening assay for identification of small molecule inhibitors of Aurora2/STK15 kinase.
J Biomol Screen
; 9(5): 391-7, 2004 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-15296638
20.
Histone modification enzymes: novel targets for cancer drugs.
Expert Opin Emerg Drugs
; 9(1): 135-54, 2004 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-15155140