Detalhe da pesquisa
1.
Adipocyte-specific mTORC2 deficiency impairs BAT and iWAT thermogenic capacity without affecting glucose uptake and energy expenditure in cold-acclimated mice.
Am J Physiol Endocrinol Metab
; 321(5): E592-E605, 2021 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34541875
2.
Adipocyte mTORC1 deficiency promotes adipose tissue inflammation and NLRP3 inflammasome activation via oxidative stress and de novo ceramide synthesis.
J Lipid Res
; 58(9): 1797-1807, 2017 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-28679588
3.
Constitutive adipocyte mTORC1 activation enhances mitochondrial activity and reduces visceral adiposity in mice.
Biochim Biophys Acta
; 1861(5): 430-8, 2016 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-26923434
4.
Chloroquine attenuates diet-induced obesity and glucose intolerance through a mechanism that might involve FGF-21, but not UCP-1-mediated thermogenesis and inhibition of adipocyte autophagy.
Mol Cell Endocrinol
; 578: 112074, 2023 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37742789
5.
Hepatic IRF3 fuels dysglycemia in obesity through direct regulation of Ppp2r1b.
Sci Transl Med
; 14(637): eabh3831, 2022 03 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-35320000
6.
PPARγ-induced upregulation of subcutaneous fat adiponectin secretion, glyceroneogenesis and BCAA oxidation requires mTORC1 activity.
Biochim Biophys Acta Mol Cell Biol Lipids
; 1866(8): 158967, 2021 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34004356
7.
Fish Oil Protects Wild Type and Uncoupling Protein 1-Deficient Mice from Obesity and Glucose Intolerance by Increasing Energy Expenditure.
Mol Nutr Food Res
; 63(7): e1800813, 2019 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30632684
8.
Constitutive Activation of the Nutrient Sensor mTORC1 in Myeloid Cells Induced by Tsc1 Deletion Protects Mice from Diet-Induced Obesity.
Mol Nutr Food Res
; 62(17): e1800283, 2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30001482
9.
PPARγ is a major regulator of branched-chain amino acid blood levels and catabolism in white and brown adipose tissues.
Metabolism
; 89: 27-38, 2018 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30316815
10.
mTORC1 inhibition with rapamycin exacerbates adipose tissue inflammation in obese mice and dissociates macrophage phenotype from function.
Immunobiology
; 222(2): 261-271, 2017 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-27692982