Detalhe da pesquisa
1.
Inherited blood cancer predisposition through altered transcription elongation.
Cell
; 187(3): 642-658.e19, 2024 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38218188
2.
A Non-catalytic Function of SETD1A Regulates Cyclin K and the DNA Damage Response.
Cell
; 172(5): 1007-1021.e17, 2018 02 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-29474905
3.
UBR5 forms ligand-dependent complexes on chromatin to regulate nuclear hormone receptor stability.
Mol Cell
; 83(15): 2753-2767.e10, 2023 08 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-37478846
4.
MLL::AF9 degradation induces rapid changes in transcriptional elongation and subsequent loss of an active chromatin landscape.
Mol Cell
; 82(6): 1140-1155.e11, 2022 03 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-35245435
5.
Epitope editing enables targeted immunotherapy of acute myeloid leukaemia.
Nature
; 621(7978): 404-414, 2023 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-37648862
6.
The menin inhibitor revumenib in KMT2A-rearranged or NPM1-mutant leukaemia.
Nature
; 615(7954): 920-924, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36922593
7.
MEN1 mutations mediate clinical resistance to menin inhibition.
Nature
; 615(7954): 913-919, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36922589
8.
It's Not What You Say But How You Say It: Targeting RNA Methylation in AML.
Mol Cell
; 78(6): 996-998, 2020 06 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-32559428
9.
A MOZ-TIF2 leukemia mouse model displays KAT6-dependent H3K23 propionylation and overexpression of a set of active developmental genes.
Proc Natl Acad Sci U S A
; 121(26): e2405905121, 2024 Jun 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-38889153
10.
Rationale for targeting BCL6 in MLL-rearranged acute lymphoblastic leukemia.
Genes Dev
; 33(17-18): 1265-1279, 2019 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31395741
11.
PI3Kγ maintains the self-renewal of acute myeloid leukemia stem cells by regulating the pentose phosphate pathway.
Blood
; 143(19): 1965-1979, 2024 May 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-38271660
12.
Mezigdomide is effective alone and in combination with menin inhibition in preclinical models of KMT2A-r and NPM1c AML.
Blood
; 143(15): 1513-1527, 2024 Apr 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-38096371
13.
Preclinical efficacy of potent and selective menin-KMT2A inhibitor JNJ-75276617 in KMT2A- and NPM1-altered leukemias.
Blood
; 2024 Jun 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-38905635
14.
AKT/FOXO signaling enforces reversible differentiation blockade in myeloid leukemias.
Cell
; 146(5): 697-708, 2011 Sep 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-21884932
15.
Histone PTM Crosstalk Stimulates Dot1 Methyltransferase Activity.
Trends Biochem Sci
; 46(7): 522-524, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33879367
16.
A UTX-MLL4-p300 Transcriptional Regulatory Network Coordinately Shapes Active Enhancer Landscapes for Eliciting Transcription.
Mol Cell
; 67(2): 308-321.e6, 2017 Jul 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-28732206
17.
The future of HOXA- expressing leukemias: Menin inhibitor response and resistance.
Curr Opin Hematol
; 31(2): 64-70, 2024 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38010951
18.
The menin-MLL1 interaction is a molecular dependency in NUP98-rearranged AML.
Blood
; 139(6): 894-906, 2022 02 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34582559
19.
Immunoproteasome function maintains oncogenic gene expression in KMT2A-complex driven leukemia.
Mol Cancer
; 22(1): 196, 2023 12 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-38049829
20.
A JAK/STAT-mediated inflammatory signaling cascade drives oncogenesis in AF10-rearranged AML.
Blood
; 137(24): 3403-3415, 2021 06 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-33690798