Detalhe da pesquisa
1.
Pyrido[3,4-d]pyrimidin-4(3H)-one metabolism mediated by aldehyde oxidase is blocked by C2-substitution.
Xenobiotica
; 47(9): 771-777, 2017 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-27618572
2.
7-(Pyrazol-4-yl)-3H-imidazo[4,5-b]pyridine-based derivatives for kinase inhibition: Co-crystallisation studies with Aurora-A reveal distinct differences in the orientation of the pyrazole N1-substituent.
Bioorg Med Chem Lett
; 25(19): 4203-9, 2015 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26296477
3.
MOARF, an Integrated Workflow for Multiobjective Optimization: Implementation, Synthesis, and Biological Evaluation.
J Chem Inf Model
; 55(6): 1169-80, 2015 Jun 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-26054755
4.
Design, synthesis and biological evaluation of 6-pyridylmethylaminopurines as CDK inhibitors.
Bioorg Med Chem
; 19(22): 6949-65, 2011 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21982796
5.
Crystal structure of an Aurora-A mutant that mimics Aurora-B bound to MLN8054: insights into selectivity and drug design.
Biochem J
; 427(1): 19-28, 2010 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20067443
6.
Structure-based design of imidazo[1,2-a]pyrazine derivatives as selective inhibitors of Aurora-A kinase in cells.
Bioorg Med Chem Lett
; 20(20): 5988-93, 2010 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20833547
7.
Fadraciclib (CYC065), a novel CDK inhibitor, targets key pro-survival and oncogenic pathways in cancer.
PLoS One
; 15(7): e0234103, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32645016
8.
Metabolism of the dual FLT-3/Aurora kinase inhibitor CCT241736 in preclinical and human in vitro models: Implication for the choice of toxicology species.
Eur J Pharm Sci
; 139: 104899, 2019 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30953752
9.
C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones: Studies towards the identification of potent, cell penetrant Jumonji C domain containing histone lysine demethylase 4 subfamily (KDM4) inhibitors, compound profiling in cell-based target engagement assays.
Eur J Med Chem
; 177: 316-337, 2019 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31158747
10.
Assessing histone demethylase inhibitors in cells: lessons learned.
Epigenetics Chromatin
; 10: 9, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28265301
11.
8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors.
J Med Chem
; 59(4): 1388-409, 2016 Feb 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-26741168
12.
Aurora isoform selectivity: design and synthesis of imidazo[4,5-b]pyridine derivatives as highly selective inhibitors of Aurora-A kinase in cells.
J Med Chem
; 56(22): 9122-35, 2013 Nov 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-24195668
13.
Structure-based design of orally bioavailable 1H-pyrrolo[3,2-c]pyridine inhibitors of mitotic kinase monopolar spindle 1 (MPS1).
J Med Chem
; 56(24): 10045-65, 2013 Dec 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-24256217
14.
Optimization of imidazo[4,5-b]pyridine-based kinase inhibitors: identification of a dual FLT3/Aurora kinase inhibitor as an orally bioavailable preclinical development candidate for the treatment of acute myeloid leukemia.
J Med Chem
; 55(20): 8721-34, 2012 Oct 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-23043539
15.
The aurora kinase inhibitor CCT137690 downregulates MYCN and sensitizes MYCN-amplified neuroblastoma in vivo.
Mol Cancer Ther
; 10(11): 2115-23, 2011 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-21885865
16.
Imidazo[4,5-b]pyridine derivatives as inhibitors of Aurora kinases: lead optimization studies toward the identification of an orally bioavailable preclinical development candidate.
J Med Chem
; 53(14): 5213-28, 2010 Jul 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-20565112
17.
Revolutionizing Resin Handling for Combinatorial Synthesis.
Angew Chem Int Ed Engl
; 40(5): 938-941, 2001 Mar 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-11241652