Detalhe da pesquisa
1.
Whole cell screen based identification of spiropiperidines with potent antitubercular properties.
Bioorg Med Chem Lett
; 25(16): 3234-45, 2015 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26087937
2.
Discovery of benzothiazoles as antimycobacterial agents: Synthesis, structure-activity relationships and binding studies with Mycobacterium tuberculosis decaprenylphosphoryl-ß-D-ribose 2'-oxidase.
Bioorg Med Chem
; 23(24): 7694-710, 2015 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26643218
3.
Optimization of pyrrolamides as mycobacterial GyrB ATPase inhibitors: structure-activity relationship and in vivo efficacy in a mouse model of tuberculosis.
Antimicrob Agents Chemother
; 58(1): 61-70, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24126580
4.
Alanine racemase mutants of Mycobacterium tuberculosis require D-alanine for growth and are defective for survival in macrophages and mice.
Microbiology (Reading)
; 158(Pt 2): 319-327, 2012 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-22075031
5.
Validation of whole genome sequencing from dried blood spots.
BMC Med Genomics
; 14(1): 110, 2021 04 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-33879142
6.
Essentiality and functional analysis of type I and type III pantothenate kinases of Mycobacterium tuberculosis.
Microbiology (Reading)
; 156(Pt 9): 2691-2701, 2010 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-20576686
7.
Optimization of Compound Plate Preparation to Address Precipitation Issue in Mammalian A549 Cytotoxicity Assay.
J Lab Autom
; 21(3): 423-31, 2016 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-26185254
8.
Revisiting the essentiality of glutamate racemase in Mycobacterium tuberculosis.
Gene
; 555(2): 269-76, 2015 Jan 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-25447907
9.
Genetic and chemical validation identifies Mycobacterium tuberculosis topoisomerase I as an attractive anti-tubercular target.
Tuberculosis (Edinb)
; 95(5): 589-98, 2015 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-26073894
10.
Triaminopyrimidine is a fast-killing and long-acting antimalarial clinical candidate.
Nat Commun
; 6: 6715, 2015 Mar 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-25823686
11.
Roles of the two type II NADH dehydrogenases in the survival of Mycobacterium tuberculosis in vitro.
Gene
; 550(1): 110-6, 2014 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25128581
12.
Diarylthiazole: an antimycobacterial scaffold potentially targeting PrrB-PrrA two-component system.
J Med Chem
; 57(15): 6572-82, 2014 Aug 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-24967731
13.
N-aryl-2-aminobenzimidazoles: novel, efficacious, antimalarial lead compounds.
J Med Chem
; 57(15): 6642-52, 2014 Aug 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-25007124
14.
Novel N-linked aminopiperidine-based gyrase inhibitors with improved hERG and in vivo efficacy against Mycobacterium tuberculosis.
J Med Chem
; 57(11): 4889-905, 2014 Jun 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-24809953
15.
Aminoazabenzimidazoles, a novel class of orally active antimalarial agents.
J Med Chem
; 57(13): 5702-13, 2014 Jul 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-24914738
16.
4-aminoquinolone piperidine amides: noncovalent inhibitors of DprE1 with long residence time and potent antimycobacterial activity.
J Med Chem
; 57(12): 5419-34, 2014 Jun 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-24871036
17.
Azaindoles: noncovalent DprE1 inhibitors from scaffold morphing efforts, kill Mycobacterium tuberculosis and are efficacious in vivo.
J Med Chem
; 56(23): 9701-8, 2013 Dec 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-24215368
18.
Evaluation of CoA biosynthesis proteins of Mycobacterium tuberculosis as potential drug targets.
Tuberculosis (Edinb)
; 92(6): 521-8, 2012 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-22954585
19.
Inactivation of the ilvB1 gene in Mycobacterium tuberculosis leads to branched-chain amino acid auxotrophy and attenuation of virulence in mice.
Microbiology (Reading)
; 155(Pt 9): 2978-2987, 2009 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-19542000