Detalhe da pesquisa
1.
Restricted Location of PSEN2/γ-Secretase Determines Substrate Specificity and Generates an Intracellular Aß Pool.
Cell
; 166(1): 193-208, 2016 Jun 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-27293189
2.
Discovery of a novel [3.2.1] benzo fused bicyclic sulfonamide-pyrazoles as potent, selective and efficacious γ-secretase inhibitors.
Bioorg Med Chem Lett
; 23(4): 996-1000, 2013 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23312944
3.
Lysine 624 of the amyloid precursor protein (APP) is a critical determinant of amyloid ß peptide length: support for a sequential model of γ-secretase intramembrane proteolysis and regulation by the amyloid ß precursor protein (APP) juxtamembrane region.
J Biol Chem
; 286(46): 39804-12, 2011 Nov 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-21868378
4.
Structural correlates of antibodies associated with acute reversal of amyloid beta-related behavioral deficits in a mouse model of Alzheimer disease.
J Biol Chem
; 285(5): 3417-27, 2010 Jan 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-19923222
5.
Discovery of sulfonamide-pyrazole gamma-secretase inhibitors.
Bioorg Med Chem Lett
; 20(7): 2148-50, 2010 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20206516
6.
Discovery of a novel sulfonamide-pyrazolopiperidine series as potent and efficacious gamma-secretase inhibitors.
Bioorg Med Chem Lett
; 20(7): 2195-9, 2010 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20207136
7.
Discovery of a novel sulfonamide-pyrazolopiperidine series as potent and efficacious gamma-secretase inhibitors (Part II).
Bioorg Med Chem Lett
; 20(12): 3502-6, 2010 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20529683
8.
N-Bridged bicyclic sulfonamides as inhibitors of gamma-secretase.
Bioorg Med Chem Lett
; 19(24): 6952-6, 2009 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19879755
9.
Crystal structure reveals conservation of amyloid-ß conformation recognized by 3D6 following humanization to bapineuzumab.
Alzheimers Res Ther
; 6(3): 31, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-25024748
10.
Evidence that enzyme processivity mediates differential Aß production by PS1 and PS2.
Curr Alzheimer Res
; 10(1): 4-10, 2013 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-22950863
11.
Treatment strategies targeting amyloid ß-protein.
Cold Spring Harb Perspect Med
; 2(9): a006387, 2012 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22951439
12.
Accelerating drug discovery for Alzheimer's disease: best practices for preclinical animal studies.
Alzheimers Res Ther
; 3(5): 28, 2011 Sep 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-21943025
13.
Amyloid precursor protein selective gamma-secretase inhibitors for treatment of Alzheimer's disease.
Alzheimers Res Ther
; 2(6): 36, 2010 Dec 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-21190552
14.
Polo-like kinase 2 (PLK2) phosphorylates alpha-synuclein at serine 129 in central nervous system.
J Biol Chem
; 284(5): 2598-2602, 2009 Jan 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-19004816
15.
Amyloid beta-protein precursor juxtamembrane domain regulates specificity of gamma-secretase-dependent cleavages.
J Biol Chem
; 282(48): 35350-60, 2007 Nov 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-17890228