Detalhe da pesquisa
1.
CCT245718, a dual FLT3/Aurora A inhibitor overcomes D835Y-mediated resistance to FLT3 inhibitors in acute myeloid leukaemia cells.
Br J Cancer
; 125(7): 966-974, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34446858
2.
Design, Synthesis and Characterization of Covalent KDM5 Inhibitors.
Angew Chem Int Ed Engl
; 58(2): 515-519, 2019 01 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-30431220
3.
Synthesis and profiling of a 3-aminopyridin-2-one-based kinase targeted fragment library: Identification of 3-amino-5-(pyridin-4-yl)pyridin-2(1H)-one scaffold for monopolar spindle 1 (MPS1) and Aurora kinases inhibition.
Bioorg Med Chem
; 26(11): 3021-3029, 2018 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29764757
4.
Pyrido[3,4-d]pyrimidin-4(3H)-one metabolism mediated by aldehyde oxidase is blocked by C2-substitution.
Xenobiotica
; 47(9): 771-777, 2017 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-27618572
5.
7-(Pyrazol-4-yl)-3H-imidazo[4,5-b]pyridine-based derivatives for kinase inhibition: Co-crystallisation studies with Aurora-A reveal distinct differences in the orientation of the pyrazole N1-substituent.
Bioorg Med Chem Lett
; 25(19): 4203-9, 2015 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26296477
6.
Regioselective C2-arylation of imidazo[4,5-b]pyridines.
Org Biomol Chem
; 11(14): 2335-47, 2013 Apr 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-23429655
7.
Crystal structure of an Aurora-A mutant that mimics Aurora-B bound to MLN8054: insights into selectivity and drug design.
Biochem J
; 427(1): 19-28, 2010 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20067443
8.
Structure-based design of imidazo[1,2-a]pyrazine derivatives as selective inhibitors of Aurora-A kinase in cells.
Bioorg Med Chem Lett
; 20(20): 5988-93, 2010 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20833547
9.
Quizartinib-resistant FLT3-ITD acute myeloid leukemia cells are sensitive to the FLT3-Aurora kinase inhibitor CCT241736.
Blood Adv
; 4(7): 1478-1491, 2020 04 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-32282883
10.
Synthesis of isothiazol-3-one derivatives as inhibitors of histone acetyltransferases (HATs).
Bioorg Med Chem
; 17(2): 467-74, 2009 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19101154
11.
Metabolism of the dual FLT-3/Aurora kinase inhibitor CCT241736 in preclinical and human in vitro models: Implication for the choice of toxicology species.
Eur J Pharm Sci
; 139: 104899, 2019 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30953752
12.
C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones: Studies towards the identification of potent, cell penetrant Jumonji C domain containing histone lysine demethylase 4 subfamily (KDM4) inhibitors, compound profiling in cell-based target engagement assays.
Eur J Med Chem
; 177: 316-337, 2019 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31158747
13.
ClTi(OiPr)3-promoted reductive amination on the solid phase: combinatorial synthesis of a biaryl-based sulfonamide library.
J Comb Chem
; 10(2): 280-4, 2008.
Artigo
em Inglês
| MEDLINE | ID: mdl-18189368
14.
Mechanism of action of the Aurora kinase inhibitor CCT129202 and in vivo quantification of biological activity.
Mol Cancer Ther
; 6(12 Pt 1): 3147-57, 2007 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-18089709
15.
Hit generation and exploration: imidazo[4,5-b]pyridine derivatives as inhibitors of Aurora kinases.
Bioorg Med Chem Lett
; 17(23): 6567-71, 2007 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17933533
16.
BGC 945, a novel tumor-selective thymidylate synthase inhibitor targeted to alpha-folate receptor-overexpressing tumors.
Cancer Res
; 65(24): 11721-8, 2005 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16357184
17.
Assessing histone demethylase inhibitors in cells: lessons learned.
Epigenetics Chromatin
; 10: 9, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28265301
18.
Selective delivery of CB300638, a cyclopenta[g]quinazoline-based thymidylate synthase inhibitor into human tumor cell lines overexpressing the alpha-isoform of the folate receptor.
Cancer Res
; 63(13): 3612-8, 2003 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-12839949
19.
Isothiazolones as inhibitors of PCAF and p300 histone acetyltransferase activity.
Mol Cancer Ther
; 4(10): 1521-32, 2005 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-16227401
20.
8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors.
J Med Chem
; 59(4): 1388-409, 2016 Feb 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-26741168