Detalhe da pesquisa
1.
Pathogenic Aß production by heterozygous PSEN1 mutations is intrinsic to the mutant protein and not mediated by conformational hindrance of wild-type PSEN1.
J Biol Chem
; 299(8): 104997, 2023 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37394008
2.
Current directions in tau research: Highlights from Tau 2020.
Alzheimers Dement
; 18(5): 988-1007, 2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-34581500
3.
The metalloprotease ADAMTS4 generates N-truncated Aß4-x species and marks oligodendrocytes as a source of amyloidogenic peptides in Alzheimer's disease.
Acta Neuropathol
; 137(2): 239-257, 2019 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30426203
4.
The role of γ-secretase activating protein (GSAP) and imatinib in the regulation of γ-secretase activity and amyloid-ß generation.
J Biol Chem
; 288(4): 2521-31, 2013 Jan 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-23209290
5.
Substrate determinants in the C99 juxtamembrane domains differentially affect γ-secretase cleavage specificity and modulator pharmacology.
J Neurochem
; 125(4): 610-9, 2013 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-23253155
6.
O-GlcNAcase Inhibitor ASN90 is a Multimodal Drug Candidate for Tau and α-Synuclein Proteinopathies.
ACS Chem Neurosci
; 13(8): 1296-1314, 2022 04 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-35357812
7.
Apoptosis in T cell acute lymphoblastic leukemia cells after cell cycle arrest induced by pharmacological inhibition of notch signaling.
Chem Biol
; 14(2): 209-19, 2007 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-17317574
8.
Gamma-secretase as a therapeutic target for the treatment of Alzheimer's disease.
Curr Pharm Des
; 11(26): 3363-82, 2005.
Artigo
em Inglês
| MEDLINE | ID: mdl-16250842
9.
Novel aspects of accumulation dynamics and A beta composition in transgenic models of AD.
Neurobiol Aging
; 25(9): 1175-85, 2004 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-15312963
10.
gamma-Secretase as a target for drug intervention in Alzheimer's disease.
Curr Opin Drug Discov Devel
; 7(5): 709-19, 2004 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-15503873
11.
Design and synthesis of highly potent benzodiazepine gamma-secretase inhibitors: preparation of (2S,3R)-3-(3,4-difluorophenyl)-2-(4-fluorophenyl)-4- hydroxy-N-((3S)-1-methyl-2-oxo-5- phenyl-2,3-dihydro-1H-benzo[e][1,4]-diazepin-3-yl)butyramide by use of an asymmetric Ireland-Claisen rearrangement.
J Med Chem
; 46(12): 2275-8, 2003 Jun 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-12773031
12.
Development and characterization of a novel membrane assay for full-length BACE-1 at pH 6.0.
J Biomol Screen
; 18(3): 277-85, 2013 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-23023105
13.
Generation and characterization of a rabbit monoclonal antibody site-specific for tau O-GlcNAcylated at serine 400.
FEBS Lett
; 587(22): 3722-8, 2013 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24113653
14.
Alzheimer's disease mutations in APP but not γ-secretase modulators affect epsilon-cleavage-dependent AICD production.
Nat Commun
; 4: 2246, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-23907250
15.
Molecular consequences of amyloid precursor protein and presenilin mutations causing autosomal-dominant Alzheimer's disease.
Alzheimers Res Ther
; 4(2): 9, 2012 Mar 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-22494386
16.
Discovery of γ-secretase modulators with a novel activity profile by text-based virtual screening.
ACS Chem Biol
; 7(9): 1488-95, 2012 Sep 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-22725102
17.
gamma-Secretase inhibitors--from molecular probes to new therapeutics?
Prog Med Chem
; 41: 99-127, 2003.
Artigo
em Inglês
| MEDLINE | ID: mdl-12774692
18.
Resveratrol is not a direct activator of SIRT1 enzyme activity.
Chem Biol Drug Des
; 74(6): 619-24, 2009 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-19843076
19.
Gamma-secretase modulation and its promise for Alzheimer's disease: a rationale for drug discovery.
Curr Top Med Chem
; 8(1): 34-7, 2008.
Artigo
em Inglês
| MEDLINE | ID: mdl-18220930
20.
Selective modulation of Abeta42 production in Alzheimer's disease: non-steroidal anti-inflammatory drugs and beyond.
Curr Pharm Des
; 12(33): 4337-55, 2006.
Artigo
em Inglês
| MEDLINE | ID: mdl-17105431