Detalhe da pesquisa
1.
Filling a nick in NIK: Extending the half-life of a NIK inhibitor through structure-based drug design.
Bioorg Med Chem Lett
; 89: 129277, 2023 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37105490
2.
Primary Amine Tethered Small Molecules Promote the Degradation of X-Linked Inhibitor of Apoptosis Protein.
J Am Chem Soc
; 143(28): 10571-10575, 2021 07 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-34236858
3.
Antibody-mediated delivery of chimeric protein degraders which target estrogen receptor alpha (ERα).
Bioorg Med Chem Lett
; 30(4): 126907, 2020 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31902710
4.
Cis-amide isosteric replacement in thienobenzoxepin inhibitors of PI3-kinase.
Bioorg Med Chem Lett
; 23(3): 897-901, 2013 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23265894
5.
Discovery of thiazolobenzoxepin PI3-kinase inhibitors that spare the PI3-kinase ß isoform.
Bioorg Med Chem Lett
; 23(9): 2606-13, 2013 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23540645
6.
Discovery and Preclinical Pharmacology of INE963, a Potent and Fast-Acting Blood-Stage Antimalarial with a High Barrier to Resistance and Potential for Single-Dose Cures in Uncomplicated Malaria.
J Med Chem
; 65(5): 3798-3813, 2022 03 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35229610
7.
Rapid synthesis of 1,3,5-substituted 1,2,4-triazoles from carboxylic acids, amidines, and hydrazines.
J Org Chem
; 76(4): 1177-9, 2011 Feb 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-21235245
8.
Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 1: Exploration of Antibody Linker, Payload Loading, and Payload Molecular Properties.
J Med Chem
; 64(5): 2534-2575, 2021 03 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33596065
9.
Medicinal Chemistry of Inhibiting RING-Type E3 Ubiquitin Ligases.
J Med Chem
; 63(15): 7957-7985, 2020 08 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-32142281
10.
Monomeric Targeted Protein Degraders.
J Med Chem
; 63(20): 11330-11361, 2020 10 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-32352776
11.
Decarboxylative ketone aldol reactions: development and mechanistic evaluation under metal-free conditions.
J Org Chem
; 74(16): 6190-8, 2009 Aug 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-20560569
12.
Ruthenium-catalyzed dehydrogenation of ammonia boranes.
J Am Chem Soc
; 130(43): 14034-5, 2008 Oct 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-18831582
13.
NF-κB inducing kinase is a therapeutic target for systemic lupus erythematosus.
Nat Commun
; 9(1): 179, 2018 01 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-29330524
14.
Scaffold-Hopping Approach To Discover Potent, Selective, and Efficacious Inhibitors of NF-κB Inducing Kinase.
J Med Chem
; 61(15): 6801-6813, 2018 08 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29940120
15.
Structure-Based Design of Tricyclic NF-κB Inducing Kinase (NIK) Inhibitors That Have High Selectivity over Phosphoinositide-3-kinase (PI3K).
J Med Chem
; 60(2): 627-640, 2017 01 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-28005357
16.
Four-component synthesis of fully substituted 1,2,4-triazoles.
Angew Chem Int Ed Engl
; 49(2): 325-8, 2010.
Artigo
em Inglês
| MEDLINE | ID: mdl-19998301
17.
Direct intramolecular arylation of unactivated arenes: application to the synthesis of aporphine alkaloids.
Chem Commun (Camb)
; (24): 2874-5, 2004 Dec 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-15599450
18.
Discovery of 2-{3-[2-(1-isopropyl-3-methyl-1H-1,2-4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl]-1H-pyrazol-1-yl}-2-methylpropanamide (GDC-0032): a ß-sparing phosphoinositide 3-kinase inhibitor with high unbound exposure and robust in vivo antitumor activity.
J Med Chem
; 56(11): 4597-610, 2013 Jun 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-23662903
19.
Heteroarylation of azine N-oxides.
Org Lett
; 14(3): 862-5, 2012 Feb 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-22260711