Detalhe da pesquisa
1.
Pathogenic monoallelic variants in GLIS3 increase type 2 diabetes risk and identify a subgroup of patients sensitive to sulfonylureas.
Diabetologia
; 67(2): 327-332, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-38051360
2.
Heterozygous pathogenic variants in POMC are not responsible for monogenic obesity: Implication for MC4R agonist use.
Genet Med
; 25(7): 100857, 2023 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-37092539
3.
Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci.
Mol Psychiatry
; 26(6): 2111-2125, 2021 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32372009
4.
A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure.
Hum Mol Genet
; 28(15): 2615-2633, 2019 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31127295
5.
A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure.
Am J Hum Genet
; 102(3): 375-400, 2018 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29455858
6.
General regression model: A "model-free" association test for quantitative traits allowing to test for the underlying genetic model.
Ann Hum Genet
; 84(3): 280-290, 2020 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-31834638
7.
Multiancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions.
Am J Epidemiol
; 188(6): 1033-1054, 2019 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30698716
8.
Pathogenic, Total Loss-of-Function DYRK1B Variants Cause Monogenic Obesity Associated With Type 2 Diabetes.
Diabetes Care
; 47(3): 444-451, 2024 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38170957
9.
A framework for conducting time-varying genome-wide association studies: An application to body mass index across childhood in six multiethnic cohorts.
medRxiv
; 2024 Mar 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-38559031
10.
Exploring the role of purinergic receptor P2RY1 in type 2 diabetes risk and pathophysiology: Insights from human functional genomics.
Mol Metab
; 79: 101867, 2024 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-38159881
11.
Bidirectional Mendelian Randomization and Multiphenotype GWAS Show Causality and Shared Pathophysiology Between Depression and Type 2 Diabetes.
Diabetes Care
; 46(9): 1707-1714, 2023 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37494602
12.
Contribution of heterozygous PCSK1 variants to obesity and implications for precision medicine: a case-control study.
Lancet Diabetes Endocrinol
; 11(3): 182-190, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36822744
13.
Human GLP1R variants affecting GLP1R cell surface expression are associated with impaired glucose control and increased adiposity.
Nat Metab
; 5(10): 1673-1684, 2023 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-37709961
14.
Biallelic Mutations in P4HTM Cause Syndromic Obesity.
Diabetes
; 72(9): 1228-1234, 2023 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37083980
15.
Gene-educational attainment interactions in a multi-population genome-wide meta-analysis identify novel lipid loci.
Front Genet
; 14: 1235337, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-38028628
16.
Rare Variant Analysis of Obesity-Associated Genes in Young Adults With Severe Obesity From a Consanguineous Population of Pakistan.
Diabetes
; 71(4): 694-705, 2022 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35061034
17.
Identification of Key Regions Mediating Human Melatonin Type 1 Receptor Functional Selectivity Revealed by Natural Variants.
ACS Pharmacol Transl Sci
; 4(5): 1614-1627, 2021 Oct 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34661078
18.
Monogenic diabetes characteristics in a transnational multicenter study from Mediterranean countries.
Diabetes Res Clin Pract
; 171: 108553, 2021 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-33242514
19.
Pathogenic variants in actionable MODY genes are associated with type 2 diabetes.
Nat Metab
; 2(10): 1126-1134, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-33046911
20.
Loss-of-function mutations in MRAP2 are pathogenic in hyperphagic obesity with hyperglycemia and hypertension.
Nat Med
; 25(11): 1733-1738, 2019 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31700171