Detalhe da pesquisa
1.
Lead optimization of an acylhydrazone scaffold possessing antiviral activity against Lassa virus.
Bioorg Med Chem Lett
; 23(21): 5840-3, 2013 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24064500
2.
Discovery and optimization of potent broad-spectrum arenavirus inhibitors derived from benzimidazole.
Bioorg Med Chem Lett
; 23(3): 744-9, 2013 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23265895
3.
Efficacy of ST-246 versus lethal poxvirus challenge in immunodeficient mice.
Proc Natl Acad Sci U S A
; 107(2): 838-43, 2010 Jan 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-20080762
4.
Pharmacokinetic comparison of a single oral dose of polymorph form i versus form V capsules of the antiorthopoxvirus compound ST-246 in human volunteers.
Antimicrob Agents Chemother
; 56(7): 3582-6, 2012 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-22526314
5.
Safety and pharmacokinetics of the anti-orthopoxvirus compound ST-246 following a single daily oral dose for 14 days in human volunteers.
Antimicrob Agents Chemother
; 56(9): 4900-5, 2012 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-22777041
6.
Safety and pharmacokinetics of the antiorthopoxvirus compound ST-246 following repeat oral dosing in healthy adult subjects.
Antimicrob Agents Chemother
; 54(6): 2560-6, 2010 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-20385870
7.
ST-246 antiviral efficacy in a nonhuman primate monkeypox model: determination of the minimal effective dose and human dose justification.
Antimicrob Agents Chemother
; 53(5): 1817-22, 2009 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-19223621
8.
Nonhuman primates are protected from smallpox virus or monkeypox virus challenges by the antiviral drug ST-246.
Antimicrob Agents Chemother
; 53(6): 2620-5, 2009 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-19349521
9.
Identification of a broad-spectrum arenavirus entry inhibitor.
J Virol
; 82(21): 10768-75, 2008 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-18715909
10.
Single-dose safety and pharmacokinetics of ST-246, a novel orthopoxvirus egress inhibitor.
Antimicrob Agents Chemother
; 52(5): 1721-7, 2008 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-18316519
11.
Discovery and development of antiviral drugs for biodefense: experience of a small biotechnology company.
Antiviral Res
; 77(1): 1-5, 2008 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-17765333
12.
Identification and characterization of potent small molecule inhibitor of hemorrhagic fever New World arenaviruses.
Antiviral Res
; 69(2): 86-97, 2006 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-16343651
13.
Pharmacokinetics and interspecies allometric scaling of ST-246, an oral antiviral therapeutic for treatment of orthopoxvirus infection.
PLoS One
; 8(4): e61514, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-23637845
14.
Evaluation of Lassa antiviral compound ST-193 in a guinea pig model.
Antiviral Res
; 90(1): 70-9, 2011 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-21371508
15.
Molecular dissection of the vaccinia virus I7L core protein proteinase.
J Virol
; 77(20): 11279-83, 2003 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-14512576
16.
The vaccinia virus I7L gene product is the core protein proteinase.
J Virol
; 76(17): 8973-6, 2002 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-12163618
17.
Biological consequences of antigen and cytokine co-expression by recombinant Streptococcus gordonii vaccine vectors.
Vaccine
; 20(17-18): 2197-205, 2002 May 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-12009273
18.
Analysis of factors affecting surface expression and immunogenicity of recombinant proteins expressed by gram-positive commensal vectors.
Infect Immun
; 70(5): 2487-91, 2002 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-11953386
19.
New class of orthopoxvirus antiviral drugs that block viral maturation.
J Virol
; 78(22): 12147-56, 2004 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-15507601