Detalhe da pesquisa
1.
Answering the Rehabilitation 2030 Call.
PM R
; 2024 Mar 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-38545734
2.
Thermodynamic and kinetic characterization of hydroxyethylamine ß-secretase-1 inhibitors.
Biochem Biophys Res Commun
; 441(2): 291-6, 2013 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24070613
3.
Design and synthesis of thiophene dihydroisoquinolines as novel BACE1 inhibitors.
Bioorg Med Chem Lett
; 23(10): 3075-80, 2013 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23570791
4.
Structure-based design of novel dihydroisoquinoline BACE-1 inhibitors that do not engage the catalytic aspartates.
Bioorg Med Chem Lett
; 23(7): 2181-6, 2013 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23465612
5.
Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: prime side chromane-containing inhibitors.
Bioorg Med Chem Lett
; 23(16): 4674-9, 2013 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23856050
6.
Discovery of a novel [3.2.1] benzo fused bicyclic sulfonamide-pyrazoles as potent, selective and efficacious γ-secretase inhibitors.
Bioorg Med Chem Lett
; 23(4): 996-1000, 2013 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23312944
7.
Design and synthesis of highly selective, orally active Polo-like kinase-2 (Plk-2) inhibitors.
Bioorg Med Chem Lett
; 23(9): 2743-9, 2013 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23522834
8.
Amino-caprolactam γ-secretase inhibitors showing potential for the treatment of Alzheimer's disease.
Bioorg Med Chem Lett
; 21(12): 3715-20, 2011 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21571529
9.
Design, synthesis and structure-activity relationship of novel [3.3.1] bicyclic sulfonamide-pyrazoles as potent γ-secretase inhibitors.
Bioorg Med Chem Lett
; 21(19): 5791-4, 2011 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21885276
10.
Discovery of a novel sulfonamide-pyrazolopiperidine series as potent and efficacious gamma-secretase inhibitors.
Bioorg Med Chem Lett
; 20(7): 2195-9, 2010 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20207136
11.
Discovery of a novel sulfonamide-pyrazolopiperidine series as potent and efficacious gamma-secretase inhibitors (Part II).
Bioorg Med Chem Lett
; 20(12): 3502-6, 2010 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20529683
12.
Improving the permeability of the hydroxyethylamine BACE-1 inhibitors: structure-activity relationship of P2' substituents.
Bioorg Med Chem Lett
; 20(16): 4789-94, 2010 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20634069
13.
Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: structure-activity relationship of the aryl region.
Bioorg Med Chem Lett
; 20(20): 6034-9, 2010 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20822903
14.
Design of an orally efficacious hydroxyethylamine (HEA) BACE-1 inhibitor in a preclinical animal model.
Bioorg Med Chem Lett
; 20(21): 6231-6, 2010 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20833041
15.
N-Bridged bicyclic sulfonamides as inhibitors of gamma-secretase.
Bioorg Med Chem Lett
; 19(24): 6952-6, 2009 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19879755
16.
Design, synthesis, and structure-activity relationship of novel orally efficacious pyrazole/sulfonamide based dihydroquinoline gamma-secretase inhibitors.
Bioorg Med Chem Lett
; 19(17): 4920-3, 2009 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19660943
17.
Design and synthesis of cell potent BACE-1 inhibitors: structure-activity relationship of P1' substituents.
Bioorg Med Chem Lett
; 19(22): 6386-91, 2009 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19811916
18.
Novel Small Molecules Targeting the Intrinsically Disordered Structural Ensemble of α-Synuclein Protect Against Diverse α-Synuclein Mediated Dysfunctions.
Sci Rep
; 9(1): 16947, 2019 11 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-31740740
19.
Have outcomes improved in trauma patients age 90 years and older over the past decade: Experience at a level II trauma center.
Am J Surg
; 215(6): 1000-1003, 2018 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29551473
20.
Troglitazone induces a rapid drop of mitochondrial membrane potential in liver HepG2 cells.
Toxicol Lett
; 155(1): 41-50, 2005 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-15585358