Pesquisa | Portal de Pesquisa da BVS Enfermagem

1.

In vivo CRISPR screens identify the E3 ligase Cop1 as a modulator of macrophage infiltration and cancer immunotherapy target.

Wang, Xiaoqing; Tokheim, Collin; Gu, Shengqing Stan; Wang, Binbin; Tang, Qin; Li, Yihao; Traugh, Nicole; Zeng, Zexian; Zhang, Yi; Li, Ziyi; Zhang, Boning; Fu, Jingxin; Xiao, Tengfei; Li, Wei; Meyer, Clifford A; Chu, Jun; Jiang, Peng; Cejas, Paloma; Lim, Klothilda; Long, Henry; Brown, Myles; Liu, X Shirley.

Cell ; 184(21): 5357-5374.e22, 2021 10 14.

Artigo em Inglês | MEDLINE | ID: mdl-34582788

2.

Enhancing Therapy: It's about Time.

Brown, Myles.

Cell ; 174(4): 771-772, 2018 08 09.

Artigo em Inglês | MEDLINE | ID: mdl-30096305

3.

Systematic characterization of mutations altering protein degradation in human cancers.

Tokheim, Collin; Wang, Xiaoqing; Timms, Richard T; Zhang, Boning; Mena, Elijah L; Wang, Binbin; Chen, Cynthia; Ge, Jun; Chu, Jun; Zhang, Wubing; Elledge, Stephen J; Brown, Myles; Liu, X Shirley.

Mol Cell ; 81(6): 1292-1308.e11, 2021 03 18.

Artigo em Inglês | MEDLINE | ID: mdl-33567269

4.

Integrative eQTL-based analyses reveal the biology of breast cancer risk loci.

Li, Qiyuan; Seo, Ji-Heui; Stranger, Barbara; McKenna, Aaron; Pe'er, Itsik; Laframboise, Thomas; Brown, Myles; Tyekucheva, Svitlana; Freedman, Matthew L.

Cell ; 152(3): 633-41, 2013 Jan 31.

Artigo em Inglês | MEDLINE | ID: mdl-23374354

5.

Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.

Shu, Shaokun; Wu, Hua-Jun; Ge, Jennifer Y; Zeid, Rhamy; Harris, Isaac S; Jovanovic, Bojana; Murphy, Katherine; Wang, Binbin; Qiu, Xintao; Endress, Jennifer E; Reyes, Jaime; Lim, Klothilda; Font-Tello, Alba; Syamala, Sudeepa; Xiao, Tengfei; Reddy Chilamakuri, Chandra Sekhar; Papachristou, Evangelia K; D'Santos, Clive; Anand, Jayati; Hinohara, Kunihiko; Li, Wei; McDonald, Thomas O; Luoma, Adrienne; Modiste, Rebecca J; Nguyen, Quang-De; Michel, Brittany; Cejas, Paloma; Kadoch, Cigall; Jaffe, Jacob D; Wucherpfennig, Kai W; Qi, Jun; Liu, X Shirley; Long, Henry; Brown, Myles; Carroll, Jason S; Brugge, Joan S; Bradner, James; Michor, Franziska; Polyak, Kornelia.

Mol Cell ; 78(6): 1096-1113.e8, 2020 06 18.

Artigo em Inglês | MEDLINE | ID: mdl-32416067

6.

Phosphorylation of EZH2 by AMPK Suppresses PRC2 Methyltransferase Activity and Oncogenic Function.

Wan, Lixin; Xu, Kexin; Wei, Yongkun; Zhang, Jinfang; Han, Tao; Fry, Christopher; Zhang, Zhao; Wang, Yao Vickie; Huang, Liyu; Yuan, Min; Xia, Weiya; Chang, Wei-Chao; Huang, Wen-Chien; Liu, Chien-Liang; Chang, Yuan-Ching; Liu, Jinsong; Wu, Yun; Jin, Victor X; Dai, Xiangpeng; Guo, Jianfeng; Liu, Jia; Jiang, Shulong; Li, Jin; Asara, John M; Brown, Myles; Hung, Mien-Chie; Wei, Wenyi.

Mol Cell ; 69(2): 279-291.e5, 2018 01 18.

Artigo em Inglês | MEDLINE | ID: mdl-29351847

7.

Cistrome Data Browser: integrated search, analysis and visualization of chromatin data.

Taing, Len; Dandawate, Ariaki; L'Yi, Sehi; Gehlenborg, Nils; Brown, Myles; Meyer, Clifford A.

Nucleic Acids Res ; 52(D1): D61-D66, 2024 Jan 05.

Artigo em Inglês | MEDLINE | ID: mdl-37971305

8.

MIRA: joint regulatory modeling of multimodal expression and chromatin accessibility in single cells.

Lynch, Allen W; Theodoris, Christina V; Long, Henry W; Brown, Myles; Liu, X Shirley; Meyer, Clifford A.

Nat Methods ; 19(9): 1097-1108, 2022 09.

Artigo em Inglês | MEDLINE | ID: mdl-36068320

9.

LLGL2 rescues nutrient stress by promoting leucine uptake in ER⁺ breast cancer.

Saito, Yasuhiro; Li, Lewyn; Coyaud, Etienne; Luna, Augustin; Sander, Chris; Raught, Brian; Asara, John M; Brown, Myles; Muthuswamy, Senthil K.

Nature ; 569(7755): 275-279, 2019 05.

Artigo em Inglês | MEDLINE | ID: mdl-30996345

10.

Inhibition of EZH2 transactivation function sensitizes solid tumors to genotoxic stress.

Liao, Yiji; Chen, Chen-Hao; Xiao, Tengfei; de la Peña Avalos, Bárbara; Dray, Eloise V; Cai, Changmeng; Gao, Shuai; Shah, Neel; Zhang, Zhao; Feit, Avery; Xue, Pengya; Liu, Zhijie; Yang, Mei; Lee, Ji Hoon; Xu, Han; Li, Wei; Mei, Shenglin; Pierre, Roodolph S; Shu, Shaokun; Fei, Teng; Duarte, Melissa; Zhao, Jin; Bradner, James E; Polyak, Kornelia; Kantoff, Philip W; Long, Henry; Balk, Steven P; Liu, X Shirley; Brown, Myles; Xu, Kexin.

Proc Natl Acad Sci U S A ; 119(3)2022 01 18.

Artigo em Inglês | MEDLINE | ID: mdl-35031563

11.

Cistrome Explorer: an interactive visual analysis tool for large-scale epigenomic data.

L'Yi, Sehi; Keller, Mark S; Dandawate, Ariaki; Taing, Len; Chen, Chen-Hao; Brown, Myles; Meyer, Clifford A; Gehlenborg, Nils.

Bioinformatics ; 39(2)2023 02 03.

Artigo em Inglês | MEDLINE | ID: mdl-36688700

12.

Androgen receptor regulates a distinct transcription program in androgen-independent prostate cancer.

Wang, Qianben; Li, Wei; Zhang, Yong; Yuan, Xin; Xu, Kexin; Yu, Jindan; Chen, Zhong; Beroukhim, Rameen; Wang, Hongyun; Lupien, Mathieu; Wu, Tao; Regan, Meredith M; Meyer, Clifford A; Carroll, Jason S; Manrai, Arjun Kumar; Jänne, Olli A; Balk, Steven P; Mehra, Rohit; Han, Bo; Chinnaiyan, Arul M; Rubin, Mark A; True, Lawrence; Fiorentino, Michelangelo; Fiore, Christopher; Loda, Massimo; Kantoff, Philip W; Liu, X Shirley; Brown, Myles.

Cell ; 138(2): 245-56, 2009 Jul 23.

Artigo em Inglês | MEDLINE | ID: mdl-19632176

13.

TISMO: syngeneic mouse tumor database to model tumor immunity and immunotherapy response.

Zeng, Zexian; Wong, Cheryl J; Yang, Lin; Ouardaoui, Nofal; Li, Dian; Zhang, Wubing; Gu, Shengqing; Zhang, Yi; Liu, Yang; Wang, Xiaoqing; Fu, Jingxin; Zhou, Liye; Zhang, Boning; Kim, Sarah; Yates, Kathleen B; Brown, Myles; Freeman, Gordon J; Uppaluri, Ravindra; Manguso, Robert; Liu, X Shirley.

Nucleic Acids Res ; 50(D1): D1391-D1397, 2022 01 07.

Artigo em Inglês | MEDLINE | ID: mdl-34534350

14.

Computational modeling of ovarian cancer dynamics suggests optimal strategies for therapy and screening.

Gu, Shengqing; Lheureux, Stephanie; Sayad, Azin; Cybulska, Paulina; Hogen, Liat; Vyarvelska, Iryna; Tu, Dongsheng; Parulekar, Wendy R; Nankivell, Matthew; Kehoe, Sean; Chi, Dennis S; Levine, Douglas A; Bernardini, Marcus Q; Rosen, Barry; Oza, Amit; Brown, Myles; Neel, Benjamin G.

Proc Natl Acad Sci U S A ; 118(25)2021 06 22.

Artigo em Inglês | MEDLINE | ID: mdl-34161278

15.

FoxA1 translates epigenetic signatures into enhancer-driven lineage-specific transcription.

Lupien, Mathieu; Eeckhoute, Jérôme; Meyer, Clifford A; Wang, Qianben; Zhang, Yong; Li, Wei; Carroll, Jason S; Liu, X Shirley; Brown, Myles.

Cell ; 132(6): 958-70, 2008 Mar 21.

Artigo em Inglês | MEDLINE | ID: mdl-18358809

16.

Response and resistance to BET bromodomain inhibitors in triple-negative breast cancer.

Shu, Shaokun; Lin, Charles Y; He, Housheng Hansen; Witwicki, Robert M; Tabassum, Doris P; Roberts, Justin M; Janiszewska, Michalina; Huh, Sung Jin; Liang, Yi; Ryan, Jeremy; Doherty, Ernest; Mohammed, Hisham; Guo, Hao; Stover, Daniel G; Ekram, Muhammad B; Brown, Jonathan; D'Santos, Clive; Krop, Ian E; Dillon, Deborah; McKeown, Michael; Ott, Christopher; Qi, Jun; Ni, Min; Rao, Prakash K; Duarte, Melissa; Wu, Shwu-Yuan; Chiang, Cheng-Ming; Anders, Lars; Young, Richard A; Winer, Eric; Letai, Antony; Barry, William T; Carroll, Jason S; Long, Henry; Brown, Myles; Liu, X Shirley; Meyer, Clifford A; Bradner, James E; Polyak, Kornelia.

Nature ; 529(7586): 413-417, 2016 Jan 21.

Artigo em Inglês | MEDLINE | ID: mdl-26735014

17.

Deciphering essential cistromes using genome-wide CRISPR screens.

Fei, Teng; Li, Wei; Peng, Jingyu; Xiao, Tengfei; Chen, Chen-Hao; Wu, Alexander; Huang, Jialiang; Zang, Chongzhi; Liu, X Shirley; Brown, Myles.

Proc Natl Acad Sci U S A ; 116(50): 25186-25195, 2019 12 10.

Artigo em Inglês | MEDLINE | ID: mdl-31727847

18.

Estrogen receptor signaling is reprogrammed during breast tumorigenesis.

Chi, David; Singhal, Hari; Li, Lewyn; Xiao, Tengfei; Liu, Weihan; Pun, Matthew; Jeselsohn, Rinath; He, Housheng; Lim, Elgene; Vadhi, Raga; Rao, Prakash; Long, Henry; Garber, Judy; Brown, Myles.

Proc Natl Acad Sci U S A ; 116(23): 11437-11443, 2019 06 04.

Artigo em Inglês | MEDLINE | ID: mdl-31110002

19.

FOXA1 upregulation promotes enhancer and transcriptional reprogramming in endocrine-resistant breast cancer.

Fu, Xiaoyong; Pereira, Resel; De Angelis, Carmine; Veeraraghavan, Jamunarani; Nanda, Sarmistha; Qin, Lanfang; Cataldo, Maria L; Sethunath, Vidyalakshmi; Mehravaran, Sepideh; Gutierrez, Carolina; Chamness, Gary C; Feng, Qin; O'Malley, Bert W; Selenica, Pier; Weigelt, Britta; Reis-Filho, Jorge S; Cohen, Ofir; Wagle, Nikhil; Nardone, Agostina; Jeselsohn, Rinath; Brown, Myles; Rimawi, Mothaffar F; Osborne, C Kent; Schiff, Rachel.

Proc Natl Acad Sci U S A ; 116(52): 26823-26834, 2019 Dec 26.

Artigo em Inglês | MEDLINE | ID: mdl-31826955

20.

Cistrome Data Browser: expanded datasets and new tools for gene regulatory analysis.

Zheng, Rongbin; Wan, Changxin; Mei, Shenglin; Qin, Qian; Wu, Qiu; Sun, Hanfei; Chen, Chen-Hao; Brown, Myles; Zhang, Xiaoyan; Meyer, Clifford A; Liu, X Shirley.

Nucleic Acids Res ; 47(D1): D729-D735, 2019 01 08.

Artigo em Inglês | MEDLINE | ID: mdl-30462313

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