Detalhe da pesquisa
1.
Characterizing the Pharmacokinetics and Biodistribution of Therapeutic Proteins: An Industry White Paper.
Drug Metab Dispos
; 50(6): 858-866, 2022 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-35149542
2.
Absorption, Distribution, Metabolism, and Excretion of Therapeutic Proteins: Current Industry Practices and Future Perspectives.
Drug Metab Dispos
; 50(6): 837-845, 2022 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-35149541
3.
Secukinumab dosing every 2 weeks demonstrated superior efficacy compared with dosing every 4 weeks in patients with psoriasis weighing 90 kg or more: results of a randomized controlled trial.
Br J Dermatol
; 186(6): 942-954, 2022 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-34981829
4.
Secukinumab demonstrates efficacy, safety, and tolerability upon administration by 2 ml autoinjector in adult patients with plaque psoriasis: 52-week results from MATURE, a randomized, placebo-controlled trial.
Dermatol Ther
; 35(3): e15285, 2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-34954841
5.
Comparison of pharmacokinetics, safety and tolerability of secukinumab administered subcutaneously using different delivery systems in healthy volunteers and in psoriasis patients.
Br J Clin Pharmacol
; 86(2): 338-351, 2020 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-31658377
6.
ß-Defensin 2 is a responsive biomarker of IL-17A-driven skin pathology in patients with psoriasis.
J Allergy Clin Immunol
; 139(3): 923-932.e8, 2017 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-27502297
7.
In reply: Use of a second ventilatory circuit when using a double-lumen endotracheal tube.
Can J Anaesth
; 67(8): 1116, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32232796
8.
Advantages of a second ventilation circuit when using a double-lumen endotracheal tube.
Can J Anaesth
; 67(6): 766-767, 2020 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-31848981
9.
Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial.
Gut
; 61(12): 1693-700, 2012 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-22595313
10.
Efficacy, tolerability, patient usability, and satisfaction with a 2 mL pre-filled syringe containing secukinumab 300 mg in patients with moderate to severe plaque psoriasis: results from the phase 3 randomized, double-blind, placebo-controlled ALLURE study.
J Dermatolog Treat
; 33(3): 1718-1726, 2022 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-33896356
11.
Secukinumab for the treatment of psoriasis, psoriatic arthritis, and axial spondyloarthritis: Physical and pharmacological properties underlie the observed clinical efficacy and safety.
Pharmacol Ther
; 229: 107925, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34171337
12.
Secukinumab distributes into dermal interstitial fluid of psoriasis patients as demonstrated by open flow microperfusion.
Exp Dermatol
; 25(2): 157-9, 2016 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-26439798
13.
Pharmacokinetics, metabolism, and disposition of deferasirox in beta-thalassemic patients with transfusion-dependent iron overload who are at pharmacokinetic steady state.
Drug Metab Dispos
; 38(5): 808-16, 2010 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-20097723
14.
Reply: To PMID 25141833.
Can J Anaesth
; 62(4): 425-6, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25884069
15.
Secukinumab Immunogenicity over 52 Weeks in Patients with Psoriatic Arthritis and Ankylosing Spondylitis.
J Rheumatol
; 47(4): 539-547, 2020 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-31203228
16.
Lung re-inflation after one-lung ventilation for thoracic surgery: importance of clamping the dependent lung.
Can J Anaesth
; 61(11): 1061, 2014 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-25141833
17.
Secukinumab Treatment Does Not Alter the Pharmacokinetics of the Cytochrome P450 3A4 Substrate Midazolam in Patients With Moderate to Severe Psoriasis.
Clin Pharmacol Ther
; 106(6): 1380-1388, 2019 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31228872
18.
The anti-IL-17A antibody secukinumab does not attenuate ozone-induced airway neutrophilia in healthy volunteers.
Eur Respir J
; 41(1): 239-41, 2013 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-23277522
19.
Pharmacokinetics, distribution, metabolism, and excretion of deferasirox and its iron complex in rats.
Drug Metab Dispos
; 36(12): 2523-38, 2008 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-18775980
20.
Population Pharmacokinetic Modeling of Secukinumab in Patients With Moderate to Severe Psoriasis.
J Clin Pharmacol
; 57(7): 876-885, 2017 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-28273356