Detalhe da pesquisa
1.
Practical synthesis of capromorelin, a growth hormone secretagogue, via a crystallization-induced dynamic resolution.
Bioorg Med Chem
; 25(3): 1000-1003, 2017 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28012686
2.
A potentiator of orthosteric ligand activity at GLP-1R acts via covalent modification.
Nat Chem Biol
; 10(8): 629-31, 2014 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-24997604
3.
Development of a selective activity-based probe for glycosylated LIPA.
Bioorg Med Chem Lett
; 26(8): 1993-6, 2016 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26965858
4.
Mechanistic characterization of a 2-thioxanthine myeloperoxidase inhibitor and selectivity assessment utilizing click chemistry--activity-based protein profiling.
Biochemistry
; 52(51): 9187-201, 2013 Dec 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-24320749
5.
Discovery of 5-phenoxy-1,3-dimethyl-1H-pyrazole-4-carboxamides as potent agonists of TGR5 via sequential combinatorial libraries.
Bioorg Med Chem Lett
; 23(5): 1407-11, 2013 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23337601
6.
Deconstruction of activity-dependent covalent modification of heme in human neutrophil myeloperoxidase by multistage mass spectrometry (MS(4)).
Biochemistry
; 51(10): 2065-77, 2012 Mar 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-22352991
7.
Discovery and evaluation of spirocyclic derivatives as antagonists of the neuropeptide Y5 receptor.
Bioorg Med Chem Lett
; 22(8): 2738-43, 2012 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22445286
8.
Identification of spirocyclic piperidine-azetidine inverse agonists of the ghrelin receptor.
Bioorg Med Chem Lett
; 22(13): 4281-7, 2012 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22677316
9.
Discovery and evaluation of pyrazolo[1,5-a]pyrimidines as neuropeptide Y1 receptor antagonists.
Bioorg Med Chem Lett
; 21(9): 2641-5, 2011 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21295475
10.
Quantitative in vitro and in vivo pharmacological profile of CE-178253, a potent and selective cannabinoid type 1 (CB1) receptor antagonist.
BMC Pharmacol
; 10: 9, 2010 Aug 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-20712891
11.
Bioisosteric replacement of the hydrazide pharmacophore of the cannabinoid-1 receptor antagonist SR141716A. Part I: potent, orally-active 1,4-disubstituted imidazoles.
Bioorg Med Chem Lett
; 19(18): 5351-4, 2009 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19683918
12.
Diabetes area patent participation analysis - part II: years 2011-2016.
Expert Opin Ther Pat
; 28(2): 111-122, 2018 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29140125
13.
Discovery and in Vitro Optimization of 3-Sulfamoylbenzamides as ROMK Inhibitors.
ACS Med Chem Lett
; 9(2): 125-130, 2018 Feb 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29456800
14.
A Small-Molecule Anti-secretagogue of PCSK9 Targets the 80S Ribosome to Inhibit PCSK9 Protein Translation.
Cell Chem Biol
; 23(11): 1362-1371, 2016 Nov 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-27746128
15.
Melanocortin-4 receptor modulators for the treatment of obesity: a patent analysis (2008-2014).
Pharm Pat Anal
; 4(2): 95-107, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-25853469
16.
Latest approaches for the treatment of obesity.
Expert Opin Drug Discov
; 10(8): 825-39, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-25967138
17.
MAP4K4 Is a Threonine Kinase That Phosphorylates FARP1.
ACS Chem Biol
; 10(12): 2667-71, 2015 Dec 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-26422651
18.
Discovery of Selective Small Molecule Inhibitors of Monoacylglycerol Acyltransferase 3.
J Med Chem
; 58(18): 7164-72, 2015 Sep 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-26258602
19.
Discovery of 2-(6-(5-Chloro-2-methoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide (PF-06282999): A Highly Selective Mechanism-Based Myeloperoxidase Inhibitor for the Treatment of Cardiovascular Diseases.
J Med Chem
; 58(21): 8513-28, 2015 Nov 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-26509551
20.
Discovery and Optimization of Imidazopyridine-Based Inhibitors of Diacylglycerol Acyltransferase 2 (DGAT2).
J Med Chem
; 58(18): 7173-85, 2015 Sep 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-26349027