Detalhe da pesquisa
1.
The Structure-Function Relationship of Human Bleomycin Hydrolase: Mutation of a Cysteine Protease into a Serine Protease.
Chembiochem
; 23(12): e202200186, 2022 06 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-35467071
2.
Characterization and Structural Determination of CmnG-A, the Adenylation Domain That Activates the Nonproteinogenic Amino Acid Capreomycidine in Capreomycin Biosynthesis.
Chembiochem
; 23(24): e202200563, 2022 12 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-36278314
3.
Engineering a High-Affinity Anti-Methoxy Poly(ethylene glycol) (mPEG) Antibody for Sensitive Immunosensing of mPEGylated Therapeutics and mPEG Molecules.
Bioconjug Chem
; 33(11): 2180-2188, 2022 11 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-36320124
4.
Biomimetic Total Synthesis of the Spiroindimicin Family of Natural Products.
Angew Chem Int Ed Engl
; 61(38): e202208802, 2022 09 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-35904849
5.
Characterization of Enzymes Catalyzing the Formation of the Nonproteinogenic Amino Acid l-Dap in Capreomycin Biosynthesis.
Biochemistry
; 60(1): 77-84, 2021 01 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33356147
6.
Terpene synthases in disguise: enzymology, structure, and opportunities of non-canonical terpene synthases.
Nat Prod Rep
; 37(3): 425-463, 2020 03 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-31650156
7.
Natural separation of the acyl-CoA ligase reaction results in a non-adenylating enzyme.
Nat Chem Biol
; 14(7): 730-737, 2018 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29867143
8.
Structural Insights into the Free-Standing Condensation Enzyme SgcC5 Catalyzing Ester-Bond Formation in the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027.
Biochemistry
; 57(23): 3278-3288, 2018 06 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-29533601
9.
PokMT1 from the Polyketomycin Biosynthetic Machinery of Streptomyces diastatochromogenes Tü6028 Belongs to the Emerging Family of C-Methyltransferases That Act on CoA-Activated Aromatic Substrates.
Biochemistry
; 57(6): 1003-1011, 2018 02 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-29341603
10.
Discovery of Alternative Producers of the Enediyne Antitumor Antibiotic C-1027 with High Titers.
J Nat Prod
; 81(3): 594-599, 2018 03 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-29345939
11.
The Mesomeric Effect of Thiazolium on non-Kekulé Diradicals in Pichia stipitis Transketolase.
Angew Chem Int Ed Engl
; 57(7): 1802-1807, 2018 02 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-29243887
12.
Cytochromes P450 for natural product biosynthesis in Streptomyces: sequence, structure, and function.
Nat Prod Rep
; 34(9): 1141-1172, 2017 08 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-28758170
13.
Crystal Structures of SgcE6 and SgcC, the Two-Component Monooxygenase That Catalyzes Hydroxylation of a Carrier Protein-Tethered Substrate during the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027 in Streptomyces globisporus.
Biochemistry
; 55(36): 5142-54, 2016 09 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-27560143
14.
Structure of the ent-Copalyl Diphosphate Synthase PtmT2 from Streptomyces platensis CB00739, a Bacterial Type II Diterpene Synthase.
J Am Chem Soc
; 138(34): 10905-15, 2016 08 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-27490479
15.
Crystal Structure of the Zorbamycin-Binding Protein ZbmA, the Primary Self-Resistance Element in Streptomyces flavoviridis ATCC21892.
Biochemistry
; 54(45): 6842-51, 2015 Nov 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-26512730
16.
Insights into the binding specificity and catalytic mechanism of N-acetylhexosamine 1-phosphate kinases through multiple reaction complexes.
Acta Crystallogr D Biol Crystallogr
; 70(Pt 5): 1401-10, 2014 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-24816108
17.
Structure and mechanism of a nonhaem-iron SAM-dependent C-methyltransferase and its engineering to a hydratase and an O-methyltransferase.
Acta Crystallogr D Biol Crystallogr
; 70(Pt 6): 1549-60, 2014 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-24914966
18.
Multiple complexes of long aliphatic N-acyltransferases lead to synthesis of 2,6-diacylated/2-acyl-substituted glycopeptide antibiotics, effectively killing vancomycin-resistant enterococcus.
J Am Chem Soc
; 136(31): 10989-95, 2014 Aug 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-25095906
19.
Biosynthesis of streptolidine involved two unexpected intermediates produced by a dihydroxylase and a cyclase through unusual mechanisms.
Angew Chem Int Ed Engl
; 53(7): 1943-8, 2014 Feb 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-24505011
20.
Crystal structure of CmnB involved in the biosynthesis of the nonproteinogenic amino acid L-2,3-diaminopropionic acid.
Acta Crystallogr F Struct Biol Commun
; 79(Pt 7): 193-199, 2023 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37405487