Detalhe da pesquisa
1.
Coarse-Grained Molecular Dynamics Simulations for Understanding the Impact of Short-Range Anisotropic Attractions on Structure and Viscosity of Concentrated Monoclonal Antibody Solutions.
Mol Pharm
; 17(5): 1748-1756, 2020 05 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32101441
2.
Self-diffusion of a highly concentrated monoclonal antibody by fluorescence correlation spectroscopy: insight into protein-protein interactions and self-association.
Soft Matter
; 15(33): 6660-6676, 2019 Aug 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-31389467
3.
Enabling Efficient Design of Biological Formulations through Advanced Characterizations.
Pharm Res
; 40(6): 1313-1316, 2023 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37407877
4.
Nanoparticulate Impurities in Pharmaceutical-Grade Sugars and their Interference with Light Scattering-Based Analysis of Protein Formulations.
Pharm Res
; 32(7): 2419-27, 2015 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-25630820
5.
Effect of pegylation on self-association of IFN-α2b.
Mol Pharm
; 11(1): 158-63, 2014 Jan 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-24266549
6.
Solution pH that minimizes self-association of three monoclonal antibodies is strongly dependent on ionic strength.
Mol Pharm
; 9(4): 744-51, 2012 Apr 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-22221144
7.
Preclinical characterization and clinical translation of pharmacodynamic markers for MK-5890: a human CD27 activating antibody for cancer immunotherapy.
J Immunother Cancer
; 10(9)2022 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36100308
8.
Understanding molecular mechanisms of biologics drug delivery and stability from NMR spectroscopy.
Adv Drug Deliv Rev
; 174: 1-29, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33609600
9.
Models for Counts and Particle Size Distributions of Subvisible Particle Data.
PDA J Pharm Sci Technol
; 75(3): 213-229, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33199515
10.
Structure, heterogeneity and developability assessment of therapeutic antibodies.
MAbs
; 11(2): 239-264, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-30543482
11.
Protein-Protein Interactions of Highly Concentrated Monoclonal Antibody Solutions via Static Light Scattering and Influence on the Viscosity.
J Phys Chem B
; 123(4): 739-755, 2019 01 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-30614707
12.
X-ray Scattering and Coarse-Grained Simulations for Clustering and Interactions of Monoclonal Antibodies at High Concentrations.
J Phys Chem B
; 123(25): 5274-5290, 2019 06 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-31146525
13.
A comparison of biophysical characterization techniques in predicting monoclonal antibody stability.
MAbs
; 8(6): 1088-97, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27210456
14.
Prediction of viral filtration performance of monoclonal antibodies based on biophysical properties of feed.
Biotechnol Prog
; 31(3): 765-74, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-25919945
15.
Improving monoclonal antibody selection and engineering using measurements of colloidal protein interactions.
J Pharm Sci
; 103(11): 3356-3363, 2014 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-25209466
16.
Insights into crowding effects on protein stability from a coarse-grained model.
J Biomech Eng
; 131(7): 071002, 2009 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-19640127
17.
Coarse-grained strategy for modeling protein stability in concentrated solutions. III: directional protein interactions.
Biophys J
; 92(12): 4316-24, 2007 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17400697
18.
Analytical model for studying how environmental factors influence protein conformational stability in solution.
J Chem Phys
; 125(22): 224903, 2006 Dec 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-17176163
19.
Heteropolymer collapse theory for protein folding in the pressure-temperature plane.
Biophys J
; 91(7): 2427-35, 2006 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16844760
20.
Coarse-grained strategy for modeling protein stability in concentrated solutions. II: phase behavior.
Biophys J
; 90(6): 1949-60, 2006 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16387768