Detalhe da pesquisa
1.
Silencing Apoe with divalent-siRNAs improves amyloid burden and activates immune response pathways in Alzheimer's disease.
Alzheimers Dement
; 20(4): 2632-2652, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38375983
2.
Diverse lipid conjugates for functional extra-hepatic siRNA delivery in vivo.
Nucleic Acids Res
; 47(3): 1082-1096, 2019 02 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-30544191
3.
Hydrophobicity drives the systemic distribution of lipid-conjugated siRNAs via lipid transport pathways.
Nucleic Acids Res
; 47(3): 1070-1081, 2019 02 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-30535404
4.
Comparison of partially and fully chemically-modified siRNA in conjugate-mediated delivery in vivo.
Nucleic Acids Res
; 46(5): 2185-2196, 2018 03 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-29432571
5.
Transvascular Delivery of Hydrophobically Modified siRNAs: Gene Silencing in the Rat Brain upon Disruption of the Blood-Brain Barrier.
Mol Ther
; 26(11): 2580-2591, 2018 11 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-30143435
6.
Exosomes Produced from 3D Cultures of MSCs by Tangential Flow Filtration Show Higher Yield and Improved Activity.
Mol Ther
; 26(12): 2838-2847, 2018 12 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30341012
7.
5Î-Vinylphosphonate improves tissue accumulation and efficacy of conjugated siRNAs in vivo.
Nucleic Acids Res
; 45(13): 7581-7592, 2017 Jul 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-28591791
8.
Synthesis and Evaluation of Parenchymal Retention and Efficacy of a Metabolically Stable O-Phosphocholine-N-docosahexaenoyl-l-serine siRNA Conjugate in Mouse Brain.
Bioconjug Chem
; 28(6): 1758-1766, 2017 06 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-28462988
9.
Exosome-mediated Delivery of Hydrophobically Modified siRNA for Huntingtin mRNA Silencing.
Mol Ther
; 24(10): 1836-1847, 2016 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27506293
10.
Guanabenz (Wytensin™) selectively enhances uptake and efficacy of hydrophobically modified siRNAs.
Nucleic Acids Res
; 43(18): 8664-72, 2015 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26400165
11.
Inhibitor of growth-4 promotes IkappaB promoter activation to suppress NF-kappaB signaling and innate immunity.
Proc Natl Acad Sci U S A
; 107(25): 11423-8, 2010 Jun 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-20534538
12.
Wnt5a inhibits B cell proliferation and functions as a tumor suppressor in hematopoietic tissue.
Cancer Cell
; 4(5): 349-60, 2003 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-14667502
13.
Mutant huntingtin messenger RNA forms neuronal nuclear clusters in rodent and human brains.
Brain Commun
; 4(6): fcac248, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36458209
14.
PK-modifying anchors significantly alter clearance kinetics, tissue distribution, and efficacy of therapeutics siRNAs.
Mol Ther Nucleic Acids
; 29: 116-132, 2022 Sep 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-35795486
15.
Bis-choline tetrathiomolybdate prevents copper-induced blood-brain barrier damage.
Life Sci Alliance
; 5(3)2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-34857647
16.
Comparative route of administration studies using therapeutic siRNAs show widespread gene modulation in Dorset sheep.
JCI Insight
; 6(24)2021 12 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-34935646
17.
The ING gene family in the regulation of cell growth and tumorigenesis.
J Cell Physiol
; 218(1): 45-57, 2009 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-18780289
18.
Deletion of p37Ing1 in mice reveals a p53-independent role for Ing1 in the suppression of cell proliferation, apoptosis, and tumorigenesis.
Cancer Res
; 67(5): 2054-61, 2007 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17332334
19.
The valency of fatty acid conjugates impacts siRNA pharmacokinetics, distribution, and efficacy in vivo.
J Control Release
; 302: 116-125, 2019 05 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-30940496
20.
A divalent siRNA chemical scaffold for potent and sustained modulation of gene expression throughout the central nervous system.
Nat Biotechnol
; 37(8): 884-894, 2019 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31375812