Detalhe da pesquisa
1.
Loss of autophagy causes a synthetic lethal deficiency in DNA repair.
Proc Natl Acad Sci U S A
; 112(3): 773-8, 2015 Jan 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-25568088
2.
A novel small-molecule MRCK inhibitor blocks cancer cell invasion.
Cell Commun Signal
; 12: 54, 2014 Oct 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-25288205
3.
Actin-myosin-based contraction is responsible for apoptotic nuclear disintegration.
J Cell Biol
; 168(2): 245-55, 2005 Jan 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-15657395
4.
The Rho GTPase effector ROCK regulates cyclin A, cyclin D1, and p27Kip1 levels by distinct mechanisms.
Mol Cell Biol
; 26(12): 4612-27, 2006 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-16738326
5.
AP-1 differentially expressed proteins Krp1 and fibronectin cooperatively enhance Rho-ROCK-independent mesenchymal invasion by altering the function, localization, and activity of nondifferentially expressed proteins.
Mol Cell Biol
; 26(4): 1480-95, 2006 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-16449658
6.
Actomyosin-Mediated Cellular Tension Drives Increased Tissue Stiffness and ß-Catenin Activation to Induce Epidermal Hyperplasia and Tumor Growth.
Cancer Cell
; 42(2): 317, 2024 Feb 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-38350422
7.
A Novel Small-Molecule Inhibitor of MRCK Prevents Radiation-Driven Invasion in Glioblastoma.
Cancer Res
; 78(22): 6509-6522, 2018 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30279244
8.
Discovery of Potent and Selective MRCK Inhibitors with Therapeutic Effect on Skin Cancer.
Cancer Res
; 78(8): 2096-2114, 2018 04 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29382705
9.
Keratinocyte differentiation is regulated by the Rho and ROCK signaling pathway.
Curr Biol
; 13(24): 2185-9, 2003 Dec 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-14680635
10.
Conditional regulation of a ROCK-estrogen receptor fusion protein.
Methods Enzymol
; 406: 541-53, 2006.
Artigo
em Inglês
| MEDLINE | ID: mdl-16472686
11.
Conditional ROCK activation in vivo induces tumor cell dissemination and angiogenesis.
Cancer Res
; 64(24): 8994-9001, 2004 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-15604264
12.
LIM kinase inhibitors disrupt mitotic microtubule organization and impair tumor cell proliferation.
Oncotarget
; 6(36): 38469-86, 2015 Nov 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-26540348
13.
Tumor regression following intravenous administration of a tumor-targeted p73 gene delivery system.
Biomaterials
; 33(9): 2701-9, 2012 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-22200536
14.
Transcriptional regulation of Rho GTPase signaling.
Transcription
; 2(5): 211-5, 2011.
Artigo
em Inglês
| MEDLINE | ID: mdl-22231116
15.
The cyclin-dependent kinase PITSLRE/CDK11 is required for successful autophagy.
Autophagy
; 7(11): 1295-301, 2011 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-21808150
16.
p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival.
Cell Res
; 21(4): 666-82, 2011 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-21079653
17.
Actomyosin-mediated cellular tension drives increased tissue stiffness and ß-catenin activation to induce epidermal hyperplasia and tumor growth.
Cancer Cell
; 19(6): 776-91, 2011 Jun 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-21665151
18.
LIM kinases are required for invasive path generation by tumor and tumor-associated stromal cells.
J Cell Biol
; 191(1): 169-85, 2010 Oct 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-20876278
19.
Regulating the conversion between rounded and elongated modes of cancer cell movement.
Cancer Cell
; 14(5): 349-51, 2008 Nov 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-18977323