Detalhe da pesquisa
1.
Towards next generation antisense oligonucleotides: mesylphosphoramidate modification improves therapeutic index and duration of effect of gapmer antisense oligonucleotides.
Nucleic Acids Res
; 49(16): 9026-9041, 2021 09 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-34417625
2.
Some ASOs that bind in the coding region of mRNAs and induce RNase H1 cleavage can cause increases in the pre-mRNAs that may blunt total activity.
Nucleic Acids Res
; 48(17): 9840-9858, 2020 09 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-32870273
3.
Golgi-endosome transport mediated by M6PR facilitates release of antisense oligonucleotides from endosomes.
Nucleic Acids Res
; 48(3): 1372-1391, 2020 02 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-31840180
4.
Understanding the effect of controlling phosphorothioate chirality in the DNA gap on the potency and safety of gapmer antisense oligonucleotides.
Nucleic Acids Res
; 48(4): 1691-1700, 2020 02 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-31980820
5.
Site-specific replacement of phosphorothioate with alkyl phosphonate linkages enhances the therapeutic profile of gapmer ASOs by modulating interactions with cellular proteins.
Nucleic Acids Res
; 47(11): 5465-5479, 2019 06 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-31034558
6.
Acute hepatotoxicity of 2' fluoro-modified 5-10-5 gapmer phosphorothioate oligonucleotides in mice correlates with intracellular protein binding and the loss of DBHS proteins.
Nucleic Acids Res
; 46(5): 2204-2217, 2018 03 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-29390093
7.
Dynamic nucleoplasmic and nucleolar localization of mammalian RNase H1 in response to RNAP I transcriptional R-loops.
Nucleic Acids Res
; 45(18): 10672-10692, 2017 Oct 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-28977560
8.
RNA cleavage products generated by antisense oligonucleotides and siRNAs are processed by the RNA surveillance machinery.
Nucleic Acids Res
; 44(7): 3351-63, 2016 Apr 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-26843429
9.
Chemical modification of PS-ASO therapeutics reduces cellular protein-binding and improves the therapeutic index.
Nat Biotechnol
; 37(6): 640-650, 2019 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-31036929
10.
Depletion of NEAT1 lncRNA attenuates nucleolar stress by releasing sequestered P54nrb and PSF to facilitate c-Myc translation.
PLoS One
; 12(3): e0173494, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28288210