Detalhe da pesquisa
1.
CRL4b Inhibition Ameliorates Experimental Autoimmune Encephalomyelitis Progression.
J Immunol
; 212(6): 982-991, 2024 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38265261
2.
Monoubiquitination empowers ubiquitin chain elongation.
J Biol Chem
; 300(3): 105753, 2024 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-38354782
3.
Modulation of Cullin-RING E3 ubiquitin ligase-dependent ubiquitination by small molecule compounds.
J Biol Chem
; 300(3): 105752, 2024 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-38354780
4.
Inhibitors of cullin-RING E3 ubiquitin ligase 4 with antitumor potential.
Proc Natl Acad Sci U S A
; 118(8)2021 02 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-33602808
5.
Acyl-CoA dehydrogenase substrate promiscuity: Challenges and opportunities for development of substrate reduction therapy in disorders of valine and isoleucine metabolism.
J Inherit Metab Dis
; 46(5): 931-942, 2023 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37309295
6.
DHTKD1 and OGDH display substrate overlap in cultured cells and form a hybrid 2-oxo acid dehydrogenase complex in vivo.
Hum Mol Genet
; 29(7): 1168-1179, 2020 05 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32160276
7.
Deletion of 2-aminoadipic semialdehyde synthase limits metabolite accumulation in cell and mouse models for glutaric aciduria type 1.
J Inherit Metab Dis
; 43(6): 1154-1164, 2020 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32567100
8.
Structure-Activity Relationships and Biological Evaluation of 7-Substituted Harmine Analogs for Human ß-Cell Proliferation.
Molecules
; 25(8)2020 Apr 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-32340326
9.
Development of indazole mineralocorticoid receptor antagonists and investigation into their selective late-stage functionalization.
Bioorg Med Chem Lett
; 29(14): 1854-1858, 2019 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31104995
10.
Benzimidazole-based DGAT1 inhibitors with a [3.1.0] bicyclohexane carboxylic acid moiety.
Bioorg Med Chem Lett
; 29(10): 1182-1186, 2019 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30926247
11.
Characterization, structure and inhibition of the human succinyl-CoA:glutarate-CoA transferase, a genetic modifier of glutaric aciduria type 1.
bioRxiv
; 2024 Feb 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-38370847
12.
Select DYRK1A Inhibitors Enhance Both Proliferation and Differentiation in Human Pancreatic Beta Cells.
bioRxiv
; 2024 May 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-38798411
13.
Characterization, Structure, and Inhibition of the Human Succinyl-CoA:glutarate-CoA Transferase, a Putative Genetic Modifier of Glutaric Aciduria Type 1.
ACS Chem Biol
; 2024 Jun 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-38915184
14.
A case of hyperlysinemia identified by urine newborn screening.
JIMD Rep
; 64(6): 440-445, 2023 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-37927488
15.
Characterization and structure of the human lysine-2-oxoglutarate reductase domain, a novel therapeutic target for treatment of glutaric aciduria type 1.
Open Biol
; 12(9): 220179, 2022 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36128717
16.
The use of stable-isotopically labeled oleic acid to interrogate lipid assembly in vivo: assessing pharmacological effects in preclinical species.
J Lipid Res
; 52(6): 1150-1161, 2011 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-21415123
17.
Targeting Cullin-RING E3 Ubiquitin Ligase 4 by Small Molecule Modulators.
J Cell Signal
; 2(3): 195-205, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34604860
18.
DYRK1A Inhibitors as Potential Therapeutics for ß-Cell Regeneration for Diabetes.
J Med Chem
; 64(6): 2901-2922, 2021 03 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-33682417
19.
Human Beta Cell Regenerative Drug Therapy for Diabetes: Past Achievements and Future Challenges.
Front Endocrinol (Lausanne)
; 12: 671946, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34335466
20.
Food colorants metabolized by commensal bacteria promote colitis in mice with dysregulated expression of interleukin-23.
Cell Metab
; 33(7): 1358-1371.e5, 2021 07 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-33989521