Detalhe da pesquisa
1.
Tandem-Cleavage Linkers Improve the In Vivo Stability and Tolerability of Antibody-Drug Conjugates.
Bioconjug Chem
; 32(4): 746-754, 2021 04 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-33689309
2.
Reconstitution of Formylglycine-generating Enzyme with Copper(II) for Aldehyde Tag Conversion.
J Biol Chem
; 290(25): 15730-15745, 2015 Jun 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-25931126
3.
Generating aldehyde-tagged antibodies with high titers and high formylglycine yields by supplementing culture media with copper(II).
BMC Biotechnol
; 16: 23, 2016 Feb 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-26911368
4.
Aldehyde tag coupled with HIPS chemistry enables the production of ADCs conjugated site-specifically to different antibody regions with distinct in vivo efficacy and PK outcomes.
Bioconjug Chem
; 25(7): 1331-41, 2014 Jul 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-24924618
5.
Variation and quantification among a target set of phosphopeptides in human plasma by multiple reaction monitoring and SWATH-MS2 data-independent acquisition.
Electrophoresis
; 35(24): 3487-97, 2014 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-24853916
6.
Polysialic acid enhances the migration and invasion of human cytotrophoblasts.
Glycobiology
; 23(5): 593-602, 2013 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-23208007
7.
Hydrazino-Pictet-Spengler ligation as a biocompatible method for the generation of stable protein conjugates.
Bioconjug Chem
; 24(6): 846-51, 2013 Jun 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-23731037
8.
Lectin chromatography/mass spectrometry discovery workflow identifies putative biomarkers of aggressive breast cancers.
J Proteome Res
; 11(4): 2508-20, 2012 Apr 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-22309216
9.
Polysialic acid governs T-cell development by regulating progenitor access to the thymus.
Proc Natl Acad Sci U S A
; 106(29): 11995-2000, 2009 Jul 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-19587240
10.
A lectin affinity workflow targeting glycosite-specific, cancer-related carbohydrate structures in trypsin-digested human plasma.
Anal Biochem
; 408(1): 71-85, 2011 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20705048
11.
Sweetening the pot: adding glycosylation to the biomarker discovery equation.
Clin Chem
; 56(2): 223-36, 2010 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-19959616
12.
Polysialic acid, a glycan with highly restricted expression, is found on human and murine leukocytes and modulates immune responses.
J Immunol
; 181(10): 6850-8, 2008 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18981104
13.
A Novel HER2-targeted Antibody-drug Conjugate Offers the Possibility of Clinical Dosing at Trastuzumab-equivalent Exposure Levels.
Mol Cancer Ther
; 19(9): 1866-1874, 2020 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32651200
14.
Maytansine-bearing antibody-drug conjugates induce in vitro hallmarks of immunogenic cell death selectively in antigen-positive target cells.
Oncoimmunology
; 8(4): e1565859, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-30906660
15.
A Case Study to Identify the Drug Conjugation Site of a Site-Specific Antibody-Drug-Conjugate Using Middle-Down Mass Spectrometry.
J Am Soc Mass Spectrom
; 30(11): 2419-2429, 2019 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-31429052
16.
Antibody-Drug Conjugates Targeting the Urokinase Receptor (uPAR) as a Possible Treatment of Aggressive Breast Cancer.
Antibodies (Basel)
; 8(4)2019 Nov 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-31694242
17.
Antibody-drug conjugate library prepared by scanning insertion of the aldehyde tag into IgG1 constant regions.
MAbs
; 10(8): 1182-1189, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-30252630
18.
CAT-02-106, a Site-Specifically Conjugated Anti-CD22 Antibody Bearing an MDR1-Resistant Maytansine Payload Yields Excellent Efficacy and Safety in Preclinical Models.
Mol Cancer Ther
; 17(1): 161-168, 2018 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29142069
19.
Recent Developments in ADC Technology: Preclinical Studies Signal Future Clinical Trends.
BioDrugs
; 31(6): 521-531, 2017 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-29119409
20.
Insights from native mass spectrometry approaches for top- and middle- level characterization of site-specific antibody-drug conjugates.
MAbs
; 9(5): 801-811, 2017 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-28406343