Detalhe da pesquisa
1.
Characterisation of intravenous pharmacokinetics in Göttingen minipig and clearance prediction using established in vitro to in vivo extrapolation methodologies.
Xenobiotica
; 52(6): 591-607, 2022 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-36000364
2.
Stress-free blood sampling in minipigs: A novel method for assessing 24-h cortisol profiles and drug effects on diurnal and ultradian rhythms.
J Pharmacol Toxicol Methods
; 127: 107504, 2024 Apr 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-38678804
3.
Practical Application of Rodent Transporter Knockout Models to Assess Brain Penetration in Drug Discovery.
Drug Metab Bioanal Lett
; 15(1): 12-21, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35196975
4.
Screening novel CNS drug candidates for P-glycoprotein interactions using the cell line iP-gp: In vitro efflux ratios from iP-gp and MDCK-MDR1 monolayers compared to brain distribution data from mice.
Eur J Pharm Biopharm
; 169: 211-219, 2021 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-34756975
5.
Phosphodiesterase type 1 inhibition alters medial prefrontal cortical activity during goal-driven behaviour and partially reverses neurophysiological deficits in the rat phencyclidine model of schizophrenia.
Neuropharmacology
; 186: 108454, 2021 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33444639
6.
P-glycoprotein differentially affects escitalopram, levomilnacipran, vilazodone and vortioxetine transport at the mouse blood-brain barrier in vivo.
Neuropharmacology
; 103: 104-11, 2016 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-26700248