Detalhe da pesquisa
1.
KRAS Allelic Imbalance Enhances Fitness and Modulates MAP Kinase Dependence in Cancer.
Cell
; 168(5): 817-829.e15, 2017 02 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-28215705
2.
A saturation mutagenesis screen uncovers resistant and sensitizing secondary KRAS mutations to clinical KRASG12C inhibitors.
Proc Natl Acad Sci U S A
; 119(18): e2120512119, 2022 05 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-35471904
3.
AzidoTMT Enables Direct Enrichment and Highly Multiplexed Quantitation of Proteome-Wide Functional Residues.
J Proteome Res
; 22(7): 2218-2231, 2023 07 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-37285454
4.
Overall survival in patients with advanced non-small cell lung cancer with KRAS G12C mutation with or without STK11 and/or KEAP1 mutations in a real-world setting.
BMC Cancer
; 23(1): 352, 2023 Apr 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-37069542
5.
Structure-based optimization of hydroxylactam as potent, cell-active inhibitors of lactate dehydrogenase.
Bioorg Med Chem Lett
; 59: 128576, 2022 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35065235
6.
Double genetic disruption of lactate dehydrogenases A and B is required to ablate the "Warburg effect" restricting tumor growth to oxidative metabolism.
J Biol Chem
; 293(41): 15947-15961, 2018 10 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30158244
7.
Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition.
Nat Chem Biol
; 12(10): 779-86, 2016 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27479743
8.
Metabolite profiling stratifies pancreatic ductal adenocarcinomas into subtypes with distinct sensitivities to metabolic inhibitors.
Proc Natl Acad Sci U S A
; 112(32): E4410-7, 2015 Aug 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-26216984
9.
Structure-Based Design and Evaluation of Reversible KRAS G13D Inhibitors.
ACS Med Chem Lett
; 15(1): 21-28, 2024 Jan 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-38229748
10.
An allosteric pan-TEAD inhibitor blocks oncogenic YAP/TAZ signaling and overcomes KRAS G12C inhibitor resistance.
Nat Cancer
; 4(6): 812-828, 2023 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37277530
11.
Forward chemical genetics in yeast for discovery of chemical probes targeting metabolism.
Molecules
; 17(11): 13098-115, 2012 Nov 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-23128089
12.
Improving treatment of severe hypertension in pregnancy and postpartum using a hypertensive pathway.
Pregnancy Hypertens
; 30: 1-6, 2022 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-35930962
13.
Identifying transcriptional programs underlying cancer drug response with TraCe-seq.
Nat Biotechnol
; 40(1): 86-93, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34531539
14.
Conformation-locking antibodies for the discovery and characterization of KRAS inhibitors.
Nat Biotechnol
; 40(5): 769-778, 2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-34992247
15.
Formins direct Arp2/3-independent actin filament assembly to polarize cell growth in yeast.
Nat Cell Biol
; 4(3): 260-9, 2002 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-11875440
16.
Formins direct Arp2/3-independent actin filament assembly to polarize cell growth in yeast.
Nat Cell Biol
; 4(1): 32-41, 2002 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-11740490
17.
A specificity map for the PDZ domain family.
PLoS Biol
; 6(9): e239, 2008 Sep 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-18828675
18.
Loss of the serine/threonine kinase fused results in postnatal growth defects and lethality due to progressive hydrocephalus.
Mol Cell Biol
; 25(16): 7054-68, 2005 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-16055717
19.
A CRISPR screen identifies MAPK7 as a target for combination with MEK inhibition in KRAS mutant NSCLC.
PLoS One
; 13(6): e0199264, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29912950
20.
Pan-Cancer Metabolic Signature Predicts Co-Dependency on Glutaminase and De Novo Glutathione Synthesis Linked to a High-Mesenchymal Cell State.
Cell Metab
; 28(3): 383-399.e9, 2018 09 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30043751