Detalhe da pesquisa
1.
DMSO-Related Effects on Ligand-Binding Properties of Lysine Methyltransferases G9a and SETD8.
Chembiochem
; 25(4): e202300809, 2024 02 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-38205880
2.
Targeting neuronal calcium channels and GSK3ß for Alzheimer's disease with naturally-inspired Diels-Alder adducts.
Bioorg Chem
; 129: 106152, 2022 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-36155094
3.
Novel 2-substituted-benzimidazole-6-sulfonamides as carbonic anhydrase inhibitors: synthesis, biological evaluation against isoforms I, II, IX and XII and molecular docking studies.
J Enzyme Inhib Med Chem
; 34(1): 1697-1710, 2019 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-31537132
4.
Successes and challenges in the development of BD1-selective BET inhibitors: a patent review.
Expert Opin Ther Pat
; : 1-17, 2024 Mar 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-38465537
5.
Prodrug Approach to Exploit (S) Alanine as Arginine Mimic Moiety in the Development of Protein Arginine Methyltransferase 4 Inhibitors.
ChemMedChem
; : e202400139, 2024 May 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-38752332
6.
NADPH Oxidases: From Molecular Mechanisms to Current Inhibitors.
J Med Chem
; 66(17): 11632-11655, 2023 09 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-37650225
7.
Identification of a Protein Arginine Methyltransferase 7 (PRMT7)/Protein Arginine Methyltransferase 9 (PRMT9) Inhibitor.
J Med Chem
; 66(19): 13665-13683, 2023 10 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-37560786
8.
First-in-Class Selective Inhibitors of the Lysine Acetyltransferase KAT8.
J Med Chem
; 66(10): 6591-6616, 2023 05 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-37155735
9.
Lysine methyltransferase inhibitors: where we are now.
RSC Chem Biol
; 3(4): 359-406, 2022 Apr 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-35441141
10.
Turning Nonselective Inhibitors of Type I Protein Arginine Methyltransferases into Potent and Selective Inhibitors of Protein Arginine Methyltransferase 4 through a Deconstruction-Reconstruction and Fragment-Growing Approach.
J Med Chem
; 65(17): 11574-11606, 2022 09 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35482954
11.
Discovery of Benzo[d]imidazole-6-sulfonamides as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with Selectivity for the First Bromodomain.
ChemMedChem
; 17(20): e202200343, 2022 10 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-36040095
12.
Development of a Microscale Thermophoresis-Based Method for Screening and Characterizing Inhibitors of the Methyl-Lysine Reader Protein MRG15.
SLAS Discov
; 26(1): 77-87, 2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32808584
13.
Two novel SIRT1 activators, SCIC2 and SCIC2.1, enhance SIRT1-mediated effects in stress response and senescence.
Epigenetics
; 15(6-7): 664-683, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-31942817
14.
Discovery of a Novel Chemotype of Histone Lysine Methyltransferase EHMT1/2 (GLP/G9a) Inhibitors: Rational Design, Synthesis, Biological Evaluation, and Co-crystal Structure.
J Med Chem
; 62(5): 2666-2689, 2019 03 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-30753076
15.
Polycyclic maleimide-based derivatives as first dual modulators of neuronal calcium channels and GSK-3ß for Alzheimer's disease treatment.
Eur J Med Chem
; 163: 394-402, 2019 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30530190
16.
Tau-Centric Multitarget Approach for Alzheimer's Disease: Development of First-in-Class Dual Glycogen Synthase Kinase 3ß and Tau-Aggregation Inhibitors.
J Med Chem
; 61(17): 7640-7656, 2018 09 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-30078314
17.
Combined HAT/EZH2 modulation leads to cancer-selective cell death.
Oncotarget
; 9(39): 25630-25646, 2018 May 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-29876013
18.
Inhibition of Wnt/ß-Catenin pathway and Histone acetyltransferase activity by Rimonabant: a therapeutic target for colon cancer.
Sci Rep
; 7(1): 11678, 2017 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28916833
19.
Chalcone-based carbamates for Alzheimer's disease treatment.
Future Med Chem
; 9(8): 749-764, 2017 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28498775
20.
Progress in the Development of Lysine Methyltransferase SETD8 Inhibitors.
ChemMedChem
; 11(16): 1680-5, 2016 08 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-27411844