Detalhe da pesquisa
1.
Mycobacterium tuberculosis Phe-tRNA synthetase: structural insights into tRNA recognition and aminoacylation.
Nucleic Acids Res
; 49(9): 5351-5368, 2021 05 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-33885823
2.
Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis.
Proc Natl Acad Sci U S A
; 116(14): 7015-7020, 2019 04 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30894487
3.
Dissecting the role of microRNAs in prostate cancer metastasis: implications for the design of novel therapeutic approaches.
Cell Mol Life Sci
; 73(13): 2531-42, 2016 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-26970978
4.
Structural insight into maternal embryonic leucine zipper kinase (MELK) conformation and inhibition toward structure-based drug design.
Biochemistry
; 52(37): 6380-7, 2013 Sep 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-23914841
5.
Small-Molecule Antibiotic Drug Development: Need and Challenges.
ACS Infect Dis
; 9(11): 2062-2071, 2023 11 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37819866
6.
Susceptibility of Ugandan Plasmodium falciparum Isolates to the Antimalarial Drug Pipeline.
Microbiol Spectr
; 11(3): e0523622, 2023 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37158739
7.
Identification and Optimization of Novel Inhibitors of the Polyketide Synthase 13 Thioesterase Domain with Antitubercular Activity.
J Med Chem
; 66(22): 15380-15408, 2023 11 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-37948640
8.
MIR205HG/LEADR Long Noncoding RNA Binds to Primed Proximal Regulatory Regions in Prostate Basal Cells Through a Triplex- and Alu-Mediated Mechanism.
Front Cell Dev Biol
; 10: 909097, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35784469
9.
NMS-P937, a 4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline derivative as potent and selective Polo-like kinase 1 inhibitor.
Bioorg Med Chem Lett
; 21(10): 2969-74, 2011 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21470862
10.
Prioritization of Molecular Targets for Antimalarial Drug Discovery.
ACS Infect Dis
; 7(10): 2764-2776, 2021 10 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34523908
11.
Thieno[3,2-c]pyrazoles: a novel class of Aurora inhibitors with favorable antitumor activity.
Bioorg Med Chem
; 18(19): 7113-20, 2010 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20817473
12.
A straightforward total synthesis of (-)-chaetominine.
Chemistry
; 15(32): 7922-7929, 2009 Aug 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-19562787
13.
A submarine journey: the pyrrole-imidazole alkaloids.
Mar Drugs
; 7(4): 705-53, 2009 Nov 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-20098608
14.
LEADeR role of miR-205 host gene as long noncoding RNA in prostate basal cell differentiation.
Nat Commun
; 10(1): 307, 2019 01 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-30659180
15.
Cdc7 kinase inhibitors: pyrrolopyridinones as potential antitumor agents. 1. Synthesis and structure-activity relationships.
J Med Chem
; 51(3): 487-501, 2008 Feb 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-18201066
16.
Biochemical and Structural Characterization of Selective Allosteric Inhibitors of the Plasmodium falciparum Drug Target, Prolyl-tRNA-synthetase.
ACS Infect Dis
; 3(1): 34-44, 2017 01 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-27798837
17.
1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazoles: identification of a potent Aurora kinase inhibitor with a favorable antitumor kinase inhibition profile.
J Med Chem
; 49(24): 7247-51, 2006 Nov 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-17125279
18.
Potent and selective Aurora inhibitors identified by the expansion of a novel scaffold for protein kinase inhibition.
J Med Chem
; 48(8): 3080-4, 2005 Apr 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-15828847
19.
Discovery of 2-[1-(4,4-Difluorocyclohexyl)piperidin-4-yl]-6-fluoro-3-oxo-2,3-dihydro-1H-isoindole-4-carboxamide (NMS-P118): A Potent, Orally Available, and Highly Selective PARP-1 Inhibitor for Cancer Therapy.
J Med Chem
; 58(17): 6875-98, 2015 Sep 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-26222319
20.
Cdc7 kinase inhibitors: 5-heteroaryl-3-carboxamido-2-aryl pyrroles as potential antitumor agents. 1. Lead finding.
J Med Chem
; 53(20): 7296-315, 2010 Oct 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-20873740