Detalhe da pesquisa
1.
Unique functional and structural properties of the LRRK2 protein ATP-binding pocket.
J Biol Chem
; 289(47): 32937-51, 2014 Nov 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-25228699
2.
LRRK2 secretion in exosomes is regulated by 14-3-3.
Hum Mol Genet
; 22(24): 4988-5000, 2013 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23886663
3.
Design and synthesis of highly selective, orally active Polo-like kinase-2 (Plk-2) inhibitors.
Bioorg Med Chem Lett
; 23(9): 2743-9, 2013 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23522834
4.
Design and synthesis of a novel, orally active, brain penetrant, tri-substituted thiophene based JNK inhibitor.
Bioorg Med Chem Lett
; 21(6): 1838-43, 2011 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21316234
5.
Design and synthesis of brain penetrant selective JNK inhibitors with improved pharmacokinetic properties for the prevention of neurodegeneration.
Bioorg Med Chem Lett
; 21(18): 5521-7, 2011 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21813278
6.
Highly selective c-Jun N-terminal kinase (JNK) 2 and 3 inhibitors with in vitro CNS-like pharmacokinetic properties prevent neurodegeneration.
Bioorg Med Chem Lett
; 21(1): 315-9, 2011 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21112785
7.
Studies with an orally bioavailable alpha V integrin antagonist in animal models of ocular vasculopathy: retinal neovascularization in mice and retinal vascular permeability in diabetic rats.
J Pharmacol Exp Ther
; 324(3): 894-901, 2008 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-18083913
8.
Targeting the tumor-promoting microenvironment in MET-amplified NSCLC cells with a novel inhibitor of pro-HGF activation.
Oncotarget
; 8(38): 63014-63025, 2017 Sep 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-28968967
9.
Validation of in vivo pharmacodynamic activity of a novel PDGF receptor tyrosine kinase inhibitor using immunohistochemistry and quantitative image analysis.
Mol Cancer Ther
; 4(8): 1198-204, 2005 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-16093435
10.
Inhibition of pro-HGF activation by SRI31215, a novel approach to block oncogenic HGF/MET signaling.
Oncotarget
; 7(20): 29492-506, 2016 May 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-27121052
11.
Design and Synthesis of Nonpeptide Inhibitors of Hepatocyte Growth Factor Activation.
ACS Med Chem Lett
; 7(2): 177-81, 2016 Feb 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-26985294
12.
(6,7-Dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamines: platelet-derived growth factor receptor tyrosine kinase inhibitors with broad antiproliferative activity against tumor cells.
J Med Chem
; 48(26): 8163-73, 2005 Dec 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-16366598
13.
Inhibition of factor Xa reduces ischemic brain damage after thromboembolic stroke in rats.
Stroke
; 34(2): 468-74, 2003 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-12574562
14.
Discovery of 1-(2-aminomethylphenyl)-3-trifluoromethyl-N- [3-fluoro-2'-(aminosulfonyl)[1,1'-biphenyl)]-4-yl]-1H-pyrazole-5-carboxyamide (DPC602), a potent, selective, and orally bioavailable factor Xa inhibitor(1).
J Med Chem
; 46(25): 5298-315, 2003 Dec 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-14640539
15.
Structure-based design of novel guanidine/benzamidine mimics: potent and orally bioavailable factor Xa inhibitors as novel anticoagulants.
J Med Chem
; 46(21): 4405-18, 2003 Oct 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-14521405
16.
Selective and brain-permeable polo-like kinase-2 (Plk-2) inhibitors that reduce α-synuclein phosphorylation in rat brain.
ChemMedChem
; 8(8): 1295-313, 2013 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-23794260
17.
Oral coadministration of ß-glucuronidase to increase exposure of extensively glucuronidated drugs that undergo enterohepatic recirculation.
J Pharm Sci
; 101(7): 2545-56, 2012 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-22473491
18.
Pyrazole-based factor Xa inhibitors containing N-arylpiperidinyl P4 residues.
Bioorg Med Chem Lett
; 17(5): 1432-7, 2007 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17174550
19.
The synthesis and SAR of 2-amino-pyrrolo[2,3-d]pyrimidines: a new class of Aurora-A kinase inhibitors.
Bioorg Med Chem Lett
; 16(22): 5778-83, 2006 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16949284
20.
Discovery of potent, efficacious, and orally bioavailable inhibitors of blood coagulation factor Xa with neutral P1 moieties.
Bioorg Med Chem Lett
; 16(21): 5584-9, 2006 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16963264