Detalhe da pesquisa
1.
Monovalent protein-degraders - Insights and future perspectives.
Bioorg Med Chem Lett
; 30(12): 127202, 2020 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32331933
2.
Identification of the endosomal sorting complex required for transport-I (ESCRT-I) as an important modulator of anti-miR uptake by cancer cells.
Nucleic Acids Res
; 43(2): 1204-15, 2015 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-25550434
3.
PIM inhibitors target CD25-positive AML cells through concomitant suppression of STAT5 activation and degradation of MYC oncogene.
Blood
; 124(11): 1777-89, 2014 Sep 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-25006129
4.
A highly potent and selective Vps34 inhibitor alters vesicle trafficking and autophagy.
Nat Chem Biol
; 10(12): 1013-9, 2014 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-25326666
5.
Evaluation of cancer dependence and druggability of PRP4 kinase using cellular, biochemical, and structural approaches.
J Biol Chem
; 288(42): 30125-30138, 2013 Oct 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-24003220
6.
Antibody-drug conjugatesa new wave of cancer drugs.
Bioorg Med Chem Lett
; 24(23): 5357-63, 2014 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25455482
7.
Preparation and optimization of new 4-(2-(indolin-1-yl)-2-oxoethyl)-2-morpholinothiazole-5-carboxylic acid and amide derivatives as potent and selective PI3Kß inhibitors.
Bioorg Med Chem Lett
; 24(6): 1506-10, 2014 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24560540
8.
Inhibitors of the p53/hdm2 protein-protein interaction-path to the clinic.
Bioorg Med Chem Lett
; 23(9): 2480-5, 2013 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23541651
9.
Inhibition of the insulin-like growth factor receptor-1 tyrosine kinase activity as a therapeutic strategy for multiple myeloma, other hematologic malignancies, and solid tumors.
Cancer Cell
; 5(3): 221-30, 2004 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-15050914
10.
In vivo antitumor activity of NVP-AEW541-A novel, potent, and selective inhibitor of the IGF-IR kinase.
Cancer Cell
; 5(3): 231-9, 2004 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-15050915
11.
The role of PTEN/Akt/PI3K signaling in the maintenance and viability of prostate cancer stem-like cell populations.
Proc Natl Acad Sci U S A
; 106(1): 268-73, 2009 Jan 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-19116269
12.
Specific apoptosis induction by the dual PI3K/mTor inhibitor NVP-BEZ235 in HER2 amplified and PIK3CA mutant breast cancer cells.
Proc Natl Acad Sci U S A
; 106(52): 22299-304, 2009 Dec 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-20007781
13.
Differential induction of apoptosis in HER2 and EGFR addicted cancers following PI3K inhibition.
Proc Natl Acad Sci U S A
; 106(46): 19503-8, 2009 Nov 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-19850869
14.
Blocking the mTOR pathway: a drug discovery perspective.
Biochem Soc Trans
; 39(2): 451-5, 2011 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-21428918
15.
From the bench to the bed side: PI3K pathway inhibitors in clinical development.
Curr Top Microbiol Immunol
; 347: 209-39, 2010.
Artigo
em Inglês
| MEDLINE | ID: mdl-20582534
16.
SAR439859, a Novel Selective Estrogen Receptor Degrader (SERD), Demonstrates Effective and Broad Antitumor Activity in Wild-Type and Mutant ER-Positive Breast Cancer Models.
Mol Cancer Ther
; 20(2): 250-262, 2021 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33310762
17.
Targeting melanoma with dual phosphoinositide 3-kinase/mammalian target of rapamycin inhibitors.
Mol Cancer Res
; 7(4): 601-13, 2009 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-19372588
18.
Synergistic action of the novel HSP90 inhibitor NVP-AUY922 with histone deacetylase inhibitors, melphalan, or doxorubicin in multiple myeloma.
Eur J Haematol
; 84(4): 337-44, 2010 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-20028416
19.
Allosteric and ATP-competitive kinase inhibitors of mTOR for cancer treatment.
Bioorg Med Chem Lett
; 20(15): 4308-12, 2010 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20561789
20.
Preclinical Activity of SAR408701: A Novel Anti-CEACAM5-maytansinoid Antibody-drug Conjugate for the Treatment of CEACAM5-positive Epithelial Tumors.
Clin Cancer Res
; 26(24): 6589-6599, 2020 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33046521