Detalhe da pesquisa
1.
7-Year (2015-21) longitudinal surveillance of lefamulin in vitro activity against bacterial pathogens collected worldwide from patients with respiratory tract infections including pneumonia and characterization of resistance mechanisms.
J Antimicrob Chemother
; 79(2): 360-369, 2024 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38113528
2.
In Vivo Immune-Modulatory Activity of Lefamulin in an Influenza Virus A (H1N1) Infection Model in Mice.
Int J Mol Sci
; 25(10)2024 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38791439
3.
Improving Traditional Registrational Trial End Points: Development and Application of a Desirability of Outcome Ranking End Point for Complicated Urinary Tract Infection Clinical Trials.
Clin Infect Dis
; 76(3): e1157-e1165, 2023 02 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-36031403
4.
Tissue Distribution of [14C]-Lefamulin into the Urogenital Tract in Rats.
Antimicrob Agents Chemother
; 66(8): e0035522, 2022 08 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-35862748
5.
Efficacy and Safety of Intravenous-to-oral Lefamulin, a Pleuromutilin Antibiotic, for the Treatment of Community-acquired Bacterial Pneumonia: The Phase III Lefamulin Evaluation Against Pneumonia (LEAP 1) Trial.
Clin Infect Dis
; 69(11): 1856-1867, 2019 11 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-30722059
6.
Antibacterial Activity of Lefamulin against Pathogens Most Commonly Causing Community-Acquired Bacterial Pneumonia: SENTRY Antimicrobial Surveillance Program (2015-2016).
Antimicrob Agents Chemother
; 63(4)2019 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30670415
7.
Low Prevalence of Gram-Positive Isolates Showing Elevated Lefamulin MIC Results during the SENTRY Surveillance Program for 2015-2016 and Characterization of Resistance Mechanisms.
Antimicrob Agents Chemother
; 63(4)2019 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30670418
8.
Pharmacokinetics and tolerability of lefamulin following intravenous and oral dosing.
J Antimicrob Chemother
; 74(Suppl 3): iii19-iii26, 2019 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30949704
9.
Pharmacokinetic/pharmacodynamic target attainment analyses to support intravenous and oral lefamulin dose selection for the treatment of patients with community-acquired bacterial pneumonia.
J Antimicrob Chemother
; 74(Suppl 3): iii35-iii41, 2019 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30949705
10.
Oral Lefamulin vs Moxifloxacin for Early Clinical Response Among Adults With Community-Acquired Bacterial Pneumonia: The LEAP 2 Randomized Clinical Trial.
JAMA
; 322(17): 1661-1671, 2019 Nov 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-31560372
11.
Reply to Tang and Lai.
Clin Infect Dis
; 71(6): 1583, 2020 09 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31822883
12.
Erratum to: Efficacy and Safety of Intravenous-to-oral Lefamulin, a Pleuromutilin Antibiotic, for the Treatment of Community-acquired Bacterial Pneumonia: The Phase III Lefamulin Evaluation Against Pneumonia (LEAP 1) Trial.
Clin Infect Dis
; 70(11): 2459, 2020 05 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-31626688
13.
Vancomycin, metronidazole, or tolevamer for Clostridium difficile infection: results from two multinational, randomized, controlled trials.
Clin Infect Dis
; 59(3): 345-54, 2014 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24799326
14.
Physiologically-based pharmacokinetic modeling of the drug-drug interaction between ivacaftor and lefamulin in cystic fibrosis patients.
CPT Pharmacometrics Syst Pharmacol
; 13(4): 589-598, 2024 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-38303579
15.
Safety and Pharmacokinetics Following Oral or Intravenous Lefamulin in Adults With Cystic Fibrosis.
Clin Ther
; 46(2): 96-103, 2024 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-38195348
16.
A plain language summary of how lefamulin alone can be used to treat pneumonia caught outside of the hospital due to common bacterial causes, including drug-resistant bacteria.
Future Microbiol
; 17: 397-410, 2022 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35285291
17.
Pooled microbiological findings and efficacy outcomes by pathogen in adults with community-acquired bacterial pneumonia from the Lefamulin Evaluation Against Pneumonia (LEAP) 1 and LEAP 2 phase 3 trials of lefamulin versus moxifloxacin.
J Glob Antimicrob Resist
; 29: 434-443, 2022 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-34788694
18.
Pharmacodynamic evaluation of lefamulin in the treatment of gonorrhea using a hollow fiber infection model simulating Neisseria gonorrhoeae infections.
Front Pharmacol
; 13: 1035841, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36452226
19.
A Multicenter Evaluation of the US Prevalence and Regional Variation in Macrolide-Resistant S. pneumoniae in Ambulatory and Hospitalized Adult Patients in the United States.
Open Forum Infect Dis
; 8(7): ofab063, 2021 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-34250183
20.
Anti-inflammatory activity of lefamulin versus azithromycin and dexamethasone in vivo and in vitro in a lipopolysaccharide-induced lung neutrophilia mouse model.
PLoS One
; 16(9): e0237659, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34587166