Detalhe da pesquisa
1.
Exploring mechanisms of FGF signalling through the lens of structural biology.
Nat Rev Mol Cell Biol
; 14(3): 166-80, 2013 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-23403721
2.
α-Klotho is a non-enzymatic molecular scaffold for FGF23 hormone signalling.
Nature
; 553(7689): 461-466, 2018 01 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-29342138
3.
Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer.
Nature
; 513(7518): 436-9, 2014 Sep 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-25043058
4.
Inhibition of fibroblast growth factor 23 (FGF23) signaling rescues renal anemia.
FASEB J
; 32(7): 3752-3764, 2018 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29481308
5.
FGF23 promotes renal calcium reabsorption through the TRPV5 channel.
EMBO J
; 33(3): 229-46, 2014 Feb 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-24434184
6.
Corrigendum: Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer.
Nature
; 520(7547): 388, 2015 Apr 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-25739500
7.
Parathyroid-specific deletion of Klotho unravels a novel calcineurin-dependent FGF23 signaling pathway that regulates PTH secretion.
PLoS Genet
; 9(12): e1003975, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-24348262
8.
The demonstration of αKlotho deficiency in human chronic kidney disease with a novel synthetic antibody.
Nephrol Dial Transplant
; 30(2): 223-33, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25324355
9.
Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor γ.
Proc Natl Acad Sci U S A
; 109(8): 3143-8, 2012 Feb 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-22315431
10.
Conversion of a paracrine fibroblast growth factor into an endocrine fibroblast growth factor.
J Biol Chem
; 287(34): 29134-46, 2012 Aug 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-22733815
11.
Isolated C-terminal tail of FGF23 alleviates hypophosphatemia by inhibiting FGF23-FGFR-Klotho complex formation.
Proc Natl Acad Sci U S A
; 107(1): 407-12, 2010 Jan 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-19966287
12.
Timing of Ketogenic Dietary Therapy (KDT) Introduction and Its Impact on Cognitive Profiles in Children with Glut1-DS-A Preliminary Study.
Children (Basel)
; 10(4)2023 Apr 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-37189930
13.
FGF21 induces PGC-1alpha and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response.
Proc Natl Acad Sci U S A
; 106(26): 10853-8, 2009 Jun 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-19541642
14.
Regulation of serum 1,25(OH)2 vitamin D3 levels by fibroblast growth factor 23 is mediated by FGF receptors 3 and 4.
Am J Physiol Renal Physiol
; 301(2): F371-7, 2011 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-21561999
15.
A homozygous missense mutation in human KLOTHO causes severe tumoral calcinosis.
J Clin Invest
; 117(9): 2684-91, 2007 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-17710231
16.
The parathyroid is a target organ for FGF23 in rats.
J Clin Invest
; 117(12): 4003-8, 2007 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-17992255
17.
In vivo genetic evidence for klotho-dependent, fibroblast growth factor 23 (Fgf23) -mediated regulation of systemic phosphate homeostasis.
FASEB J
; 23(2): 433-41, 2009 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-18835926
18.
Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members.
Mol Cell Biol
; 27(9): 3417-28, 2007 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-17339340
19.
FGF23 decreases renal NaPi-2a and NaPi-2c expression and induces hypophosphatemia in vivo predominantly via FGF receptor 1.
Am J Physiol Renal Physiol
; 297(2): F282-91, 2009 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-19515808
20.
A G protein-coupled, IP3/protein kinase C pathway controlling the synthesis of phosphaturic hormone FGF23.
JCI Insight
; 4(17)2019 09 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-31484825