Detalhe da pesquisa
1.
A p53 score derived from TP53 CRISPR/Cas9 HMCLs predicts survival and reveals a major role of BAX in the response to BH3 mimetics.
Blood
; 143(13): 1242-1258, 2024 Mar 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-38096363
2.
Disruption of IRE1α through its kinase domain attenuates multiple myeloma.
Proc Natl Acad Sci U S A
; 116(33): 16420-16429, 2019 08 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-31371506
3.
BH3-mimetic toolkit guides the respective use of BCL2 and MCL1 BH3-mimetics in myeloma treatment.
Blood
; 132(25): 2656-2669, 2018 12 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-30309889
4.
RITA (Reactivating p53 and Inducing Tumor Apoptosis) is efficient against TP53abnormal myeloma cells independently of the p53 pathway.
BMC Cancer
; 14: 437, 2014 Jun 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-24927749
5.
The selectivity of Marinopyrrole A to induce apoptosis in MCL1high BCL2low expressing myeloma cells is related to its ability to impair protein translation.
Br J Haematol
; 180(1): 157-159, 2018 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27523575
6.
ABT-737 is highly effective against molecular subgroups of multiple myeloma.
Blood
; 118(14): 3901-10, 2011 Oct 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-21835956
7.
BCLXL PROTAC degrader DT2216 targets secondary plasma cell leukemia addicted to BCLXL for survival.
Front Oncol
; 13: 1196005, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37534243
8.
BH3 profiling as a tool to identify acquired resistance to venetoclax in multiple myeloma.
Br J Haematol
; 179(4): 684-688, 2017 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-27471002
9.
Noxa controls Mule-dependent Mcl-1 ubiquitination through the regulation of the Mcl-1/USP9X interaction.
Biochem Biophys Res Commun
; 413(3): 460-4, 2011 Sep 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-21907705
10.
A simple flow cytometry-based barcode for routine authentication of multiple myeloma and mantle cell lymphoma cell lines.
Cytometry A
; 87(4): 285-8, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25688540
11.
Restoring Apoptosis with BH3 Mimetics in Mature B-Cell Malignancies.
Cells
; 9(3)2020 03 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-32183335
12.
Dual targeting of BCL2 and MCL1 rescues myeloma cells resistant to BCL2 and MCL1 inhibitors associated with the formation of BAX/BAK hetero-complexes.
Cell Death Dis
; 11(5): 316, 2020 05 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32371863
13.
Noxa up-regulation and Mcl-1 cleavage are associated to apoptosis induction by bortezomib in multiple myeloma.
Cancer Res
; 67(11): 5418-24, 2007 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17545623
14.
BCL2-Family Dysregulation in B-Cell Malignancies: From Gene Expression Regulation to a Targeted Therapy Biomarker.
Front Oncol
; 8: 645, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-30666297
15.
Whole-exon sequencing of human myeloma cell lines shows mutations related to myeloma patients at relapse with major hits in the DNA regulation and repair pathways.
J Hematol Oncol
; 11(1): 137, 2018 12 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-30545397
16.
Melphalan-induced apoptosis in multiple myeloma cells is associated with a cleavage of Mcl-1 and Bim and a decrease in the Mcl-1/Bim complex.
Oncogene
; 24(54): 8076-9, 2005 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16091744
17.
Repression of Mcl-1 and disruption of the Mcl-1/Bak interaction in myeloma cells couple ER stress to mitochondrial apoptosis.
Cancer Lett
; 383(2): 204-211, 2016 12 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-27697610
18.
BCL-B (BCL2L10) is overexpressed in patients suffering from multiple myeloma (MM) and drives an MM-like disease in transgenic mice.
J Exp Med
; 213(9): 1705-22, 2016 08 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-27455953
19.
Dexamethasone-induced cell death is restricted to specific molecular subgroups of multiple myeloma.
Oncotarget
; 6(29): 26922-34, 2015 Sep 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-26323097
20.
Curcumin induces cell death of the main molecular myeloma subtypes, particularly the poor prognosis subgroups.
Cancer Biol Ther
; 16(1): 60-5, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-25517601