Detalhe da pesquisa
1.
Tuning cytokine receptor signaling by re-orienting dimer geometry with surrogate ligands.
Cell
; 160(6): 1196-208, 2015 Mar 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-25728669
2.
microRNAs signatures as potential biomarkers of structural cardiotoxicity in human-induced pluripotent stem-cell derived cardiomyocytes.
Arch Toxicol
; 96(7): 2033-2047, 2022 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35488128
3.
An incomplete trafficking defect to the cell-surface leads to paradoxical thrombocytosis for human and murine MPL P106L.
Blood
; 128(26): 3146-3158, 2016 12 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-28034873
4.
Thrombopoietin receptor activation by myeloproliferative neoplasm associated calreticulin mutants.
Blood
; 127(10): 1325-35, 2016 Mar 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-26668133
5.
New pathogenic mechanisms induced by germline erythropoietin receptor mutations in primary erythrocytosis.
Haematologica
; 103(4): 575-586, 2018 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29269524
6.
Innovative organotypic in vitro models for safety assessment: aligning with regulatory requirements and understanding models of the heart, skin, and liver as paradigms.
Arch Toxicol
; 92(2): 557-569, 2018 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-29362863
7.
His499 Regulates Dimerization and Prevents Oncogenic Activation by Asparagine Mutations of the Human Thrombopoietin Receptor.
J Biol Chem
; 291(6): 2974-87, 2016 Feb 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-26627830
8.
Novel activating mutations lacking cysteine in type I cytokine receptors in acute lymphoblastic leukemia.
Blood
; 124(1): 106-10, 2014 Jul 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-24787007
9.
Tryptophan at the transmembrane-cytosolic junction modulates thrombopoietin receptor dimerization and activation.
Proc Natl Acad Sci U S A
; 110(7): 2540-5, 2013 Feb 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-23359689
10.
Phosphoprotein expression profiles in rat kidney injury: Source for potential mechanistic biomarkers.
J Cell Mol Med
; 23(3): 2251-2255, 2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30636369
11.
Activating Janus kinase pseudokinase domain mutations in myeloproliferative and other blood cancers.
Biochem Soc Trans
; 41(4): 1048-54, 2013 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-23863177
12.
Testing the nonclinical Comprehensive In Vitro Proarrhythmia Assay (CiPA) paradigm with an established anti-seizure medication: Levetiracetam case study.
Pharmacol Res Perspect
; 11(1): e01059, 2023 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36748725
13.
Preliminary study of thyroid and colon cancers-associated antigens and their cognate autoantibodies as potential cancer biomarkers.
Biomarkers
; 17(4): 362-71, 2012 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-22612312
14.
Discovery and Characterization of Potent, Efficacious, Orally Available Antimalarial Plasmepsin X Inhibitors and Preclinical Safety Assessment of UCB7362.
J Med Chem
; 65(20): 14121-14143, 2022 10 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-36216349
15.
Applying the CiPA approach to evaluate cardiac proarrhythmia risk of some antimalarials used off-label in the first wave of COVID-19.
Clin Transl Sci
; 14(3): 1133-1146, 2021 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33620150
16.
A Targeted Metabolomics-Based Assay Using Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Identifies Structural and Functional Cardiotoxicity Potential.
Toxicol Sci
; 174(2): 218-240, 2020 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32040181
17.
INSPIRE: A European training network to foster research and training in cardiovascular safety pharmacology.
J Pharmacol Toxicol Methods
; 105: 106889, 2020 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-32565326
18.
Monoclonal antibody MX35 detects the membrane transporter NaPi2b (SLC34A2) in human carcinomas.
Cancer Immun
; 8: 3, 2008 Feb 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-18251464
19.
miR-21-5p as a potential biomarker of inflammatory infiltration in the heart upon acute drug-induced cardiac injury in rats.
Toxicol Lett
; 286: 31-38, 2018 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-29355689
20.
Fatty-Acid Binding Protein 4 (FABP4) as a Potential Preclinical Biomarker of Drug-Induced Kidney Injury.
Toxicol Sci
; 166(2): 441-450, 2018 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30215792