Detalhe da pesquisa
1.
Genotoxicity Assessment of Drug Metabolites in the Context of MIST and Beyond.
Chem Res Toxicol
; 33(1): 10-19, 2020 01 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-31859487
2.
An appraisal of critical effect sizes for the benchmark dose approach to assess dose-response relationships in genetic toxicology.
Arch Toxicol
; 91(12): 3799-3807, 2017 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-28799093
3.
Correction to: An appraisal of critical effect sizes for the benchmark dose approach to assess dose-response relationships in genetic toxicology.
Arch Toxicol
; 91(12): 3809, 2017 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-29128924
4.
A proposal for a novel rationale for critical effect size in dose-response analysis based on a multi-endpoint in vivo study with methyl methanesulfonate.
Mutagenesis
; 31(3): 239-53, 2016 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-26590612
5.
Genotoxicity assessment of peptide/protein-related biotherapeutics: points to consider before testing.
Mutagenesis
; 31(4): 375-84, 2016 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-27000792
6.
Genotoxicity testing of peptides: folate deprivation as a marker of exaggerated pharmacology.
Toxicol Appl Pharmacol
; 279(3): 419-427, 2014 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24997324
7.
In vitro genotoxicity of neutral red after photo-activation and metabolic activation in the Ames test, the micronucleus test and the comet assay.
Mutat Res
; 746(1): 15-20, 2012 Jul 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-22414563
8.
A comparison of transgenic rodent mutation and in vivo comet assay responses for 91 chemicals.
Mutat Res Genet Toxicol Environ Mutagen
; 839: 21-35, 2019 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-30744809
9.
DNA Damage Response of 4-Chloro-Ortho-Toluidine in Various Rat Tissues.
Toxicol Sci
; 163(2): 516-524, 2018 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29579244
10.
Discovery of Risdiplam, a Selective Survival of Motor Neuron-2 ( SMN2) Gene Splicing Modifier for the Treatment of Spinal Muscular Atrophy (SMA).
J Med Chem
; 61(15): 6501-6517, 2018 Aug 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30044619
11.
Locked nucleic acid (LNA): Based single-stranded oligonucleotides are not genotoxic.
Environ Mol Mutagen
; 58(3): 112-121, 2017 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-28295562
12.
Interlaboratory evaluation of a multiplexed high information content in vitro genotoxicity assay.
Environ Mol Mutagen
; 58(3): 146-161, 2017 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-28370322
13.
Clinical trial considerations on male contraception and collection of pregnancy information from female partner: update.
Clin Transl Med
; 5(1): 23, 2016 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-27455840
14.
Inter-laboratory comparison of the in vivo comet assay including three image analysis systems.
Environ Mol Mutagen
; 56(9): 788-93, 2015 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-26248301
15.
IWGT report on quantitative approaches to genotoxicity risk assessment I. Methods and metrics for defining exposure-response relationships and points of departure (PoDs).
Mutat Res Genet Toxicol Environ Mutagen
; 783: 55-65, 2015 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25953400
16.
IWGT report on quantitative approaches to genotoxicity risk assessment II. Use of point-of-departure (PoD) metrics in defining acceptable exposure limits and assessing human risk.
Mutat Res Genet Toxicol Environ Mutagen
; 783: 66-78, 2015 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25953401
17.
Quantitative assessment of the dose-response of alkylating agents in DNA repair proficient and deficient ames tester strains.
Environ Mol Mutagen
; 55(1): 15-23, 2014 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-24273186
18.
Performance and data interpretation of the in vivo comet assay in pharmaceutical industry: EFPIA survey results.
Mutat Res Genet Toxicol Environ Mutagen
; 775-776: 81-8, 2014 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-25435358
19.
Genotoxicity profile of azidothymidine in vitro.
Toxicol Sci
; 135(2): 317-27, 2013 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-23811827
20.
Assessment of the genotoxic potential of azidothymidine in the comet, micronucleus, and Pig-a assay.
Toxicol Sci
; 135(2): 309-16, 2013 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-23811826