Detalhe da pesquisa
1.
Discovery of novel benzothiophene derivatives as potent and narrow spectrum inhibitors of DYRK1A and DYRK1B.
Bioorg Med Chem Lett
; 68: 128764, 2022 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35504513
2.
Novel Dihydropteridinone Derivatives As Potent Inhibitors of the Understudied Human Kinases Vaccinia-Related Kinase 1 and Casein Kinase 1δ/ε.
J Med Chem
; 2024 May 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-38780468
3.
From partial to full agonism: identification of a novel 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole as a full agonist of the human GPR119 receptor.
Bioorg Med Chem Lett
; 23(1): 194-7, 2013 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23177788
4.
Deconstruction of activity-dependent covalent modification of heme in human neutrophil myeloperoxidase by multistage mass spectrometry (MS(4)).
Biochemistry
; 51(10): 2065-77, 2012 Mar 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-22352991
5.
Identification of novel series of pyrazole and indole-urea based DFG-out PYK2 inhibitors.
Bioorg Med Chem Lett
; 22(24): 7523-9, 2012 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23153798
6.
Use of 3D properties to characterize beyond rule-of-5 property space for passive permeation.
J Chem Inf Model
; 52(4): 882-90, 2012 Apr 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-22394163
7.
Exploring aromatic chemical space with NEAT: novel and electronically equivalent aromatic template.
J Chem Inf Model
; 52(5): 1114-23, 2012 May 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-22486394
8.
Design and evaluation of a 2-(2,3,6-trifluorophenyl)acetamide derivative as an agonist of the GPR119 receptor.
Bioorg Med Chem Lett
; 21(5): 1306-9, 2011 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21310611
9.
Understanding the impact of the P-loop conformation on kinase selectivity.
J Chem Inf Model
; 51(6): 1199-204, 2011 Jun 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-21568278
10.
Addressing limitations with the MM-GB/SA scoring procedure using the WaterMap method and free energy perturbation calculations.
J Chem Inf Model
; 50(4): 547-59, 2010 Apr 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-20235592
11.
Thermodynamic analysis of mRNA cap binding by the human initiation factor eIF4E via free energy perturbations.
J Am Chem Soc
; 131(50): 18139-46, 2009 Dec 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-19924990
12.
Development of Pyridine-based Inhibitors for the Human Vaccinia-related Kinases 1 and 2.
ACS Med Chem Lett
; 10(9): 1266-1271, 2019 Sep 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31531195
13.
2-Aminopyridine-Based Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) Inhibitors: Assessment of Mechanism-Based Safety.
J Med Chem
; 61(7): 3114-3125, 2018 04 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-29570292
14.
From docking false-positive to active anti-HIV agent.
J Med Chem
; 50(22): 5324-9, 2007 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17918923
15.
Structural characterization of human Vaccinia-Related Kinases (VRK) bound to small-molecule inhibitors identifies different P-loop conformations.
Sci Rep
; 7(1): 7501, 2017 08 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-28790404
16.
Discovery of a potent, selective, and efficacious class of reversible alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase effective as analgesics.
J Med Chem
; 48(6): 1849-56, 2005 Mar 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-15771430
17.
Discovery of an in Vivo Tool to Establish Proof-of-Concept for MAP4K4-Based Antidiabetic Treatment.
ACS Med Chem Lett
; 6(11): 1128-33, 2015 Nov 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-26617966
18.
Enantioselective hydroarylation of bridged [3.2.1] heterocycles: an efficient entry into the homoepibatidine skeleton.
Org Lett
; 15(13): 3424-7, 2013 Jul 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-23790034
19.
Design and synthesis of diazatricyclodecane agonists of the G-protein-coupled receptor 119.
J Med Chem
; 56(1): 301-19, 2013 Jan 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-23234271
20.
MM-GB/SA rescoring of docking poses.
Methods Mol Biol
; 819: 255-68, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-22183542