Detalhe da pesquisa
1.
Author Correction: c-Kit-positive ILC2s exhibit an ILC3-like signature that may contribute to IL-17-mediated pathologies.
Nat Immunol
; 21(1): 101, 2020 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-31723260
2.
c-Kit-positive ILC2s exhibit an ILC3-like signature that may contribute to IL-17-mediated pathologies.
Nat Immunol
; 20(8): 992-1003, 2019 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31263279
3.
Topological requirements and signaling properties of T cell-activating, anti-CD28 antibody superagonists.
J Exp Med
; 197(8): 955-66, 2003 Apr 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-12707299
4.
Lack of evidence for expression and function of IL-39 in human immune cells.
PLoS One
; 15(12): e0242329, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-33259477
5.
The potent protein kinase C-selective inhibitor AEB071 (sotrastaurin) represents a new class of immunosuppressive agents affecting early T-cell activation.
J Pharmacol Exp Ther
; 330(3): 792-801, 2009 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-19491325
6.
Antagonizing Retinoic Acid-Related-Orphan Receptor Gamma Activity Blocks the T Helper 17/Interleukin-17 Pathway Leading to Attenuated Pro-inflammatory Human Keratinocyte and Skin Responses.
Front Immunol
; 10: 577, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-30972071
7.
Structure-Based and Property-Driven Optimization of N-Aryl Imidazoles toward Potent and Selective Oral RORγt Inhibitors.
J Med Chem
; 62(23): 10816-10832, 2019 12 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31729873
8.
Interferon regulatory factor 5 and nuclear factor kappa-B exhibit cooperating but also divergent roles in the regulation of pro-inflammatory cytokines important for the development of TH1 and TH17 responses.
FEBS J
; 285(16): 3097-3113, 2018 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29971953
9.
Optimizing a Weakly Binding Fragment into a Potent RORγt Inverse Agonist with Efficacy in an in Vivo Inflammation Model.
J Med Chem
; 61(15): 6724-6735, 2018 08 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29990434
10.
Gene silencing of HIV chemokine receptors using ribozymes and single-stranded antisense RNA.
Biochem J
; 394(Pt 2): 511-8, 2006 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16293105
11.
Structural States of RORγt: X-ray Elucidation of Molecular Mechanisms and Binding Interactions for Natural and Synthetic Compounds.
ChemMedChem
; 12(13): 1014-1021, 2017 07 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-28590087
12.
Pharmacological inhibition of RORγt suppresses the Th17 pathway and alleviates arthritis in vivo.
PLoS One
; 12(11): e0188391, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-29155882
13.
Retinoic-acid-orphan-receptor-C inhibition suppresses Th17 cells and induces thymic aberrations.
JCI Insight
; 2(5): e91127, 2017 03 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-28289717
14.
Synthesis and Biological Evaluation of New Triazolo- and Imidazolopyridine RORγt Inverse Agonists.
ChemMedChem
; 11(24): 2640-2648, 2016 12 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-27902884
15.
CTLA-4 suppresses proximal TCR signaling in resting human CD4(+) T cells by inhibiting ZAP-70 Tyr(319) phosphorylation: a potential role for tyrosine phosphatases.
J Immunol
; 168(9): 4420-9, 2002 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-11970985