Detalhe da pesquisa
1.
Discovery of 6-Oxo-4-phenyl-hexanoic acid derivatives as RORγt inverse agonists showing favorable ADME profile.
Bioorg Med Chem Lett
; 36: 127786, 2021 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33493627
2.
Analyzing Learned Molecular Representations for Property Prediction.
J Chem Inf Model
; 59(8): 3370-3388, 2019 08 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-31361484
3.
Discovery of a biarylamide series of potent, state-dependent NaV1.7 inhibitors.
Bioorg Med Chem Lett
; 27(16): 3817-3824, 2017 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28684121
4.
The discovery of benzoxazine sulfonamide inhibitors of NaV1.7: Tools that bridge efficacy and target engagement.
Bioorg Med Chem Lett
; 27(15): 3477-3485, 2017 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28629594
5.
Identification of a novel conformationally constrained glucagon receptor antagonist.
Bioorg Med Chem Lett
; 24(3): 839-44, 2014 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24418771
6.
Correction to Analyzing Learned Molecular Representations for Property Prediction.
J Chem Inf Model
; 59(12): 5304-5305, 2019 Dec 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-31814400
7.
The design and synthesis of a potent glucagon receptor antagonist with favorable physicochemical and pharmacokinetic properties as a candidate for the treatment of type 2 diabetes mellitus.
Bioorg Med Chem Lett
; 23(10): 3051-8, 2013 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23562063
8.
Pyrimidone-based series of glucokinase activators with alternative donor-acceptor motif.
Bioorg Med Chem Lett
; 23(16): 4571-8, 2013 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23831135
9.
Defining the key pharmacophore elements of PF-04620110: discovery of a potent, orally-active, neutral DGAT-1 inhibitor.
Bioorg Med Chem
; 21(17): 5081-97, 2013 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23871442
10.
Precision Oncology Comes of Age: Designing Best-in-Class Small Molecules by Integrating Two Decades of Advances in Chemistry, Target Biology, and Data Science.
Cancer Discov
; 13(10): 2131-2149, 2023 10 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37712571
11.
STX-478, a Mutant-Selective, Allosteric PI3Kα Inhibitor Spares Metabolic Dysfunction and Improves Therapeutic Response in PI3Kα-Mutant Xenografts.
Cancer Discov
; 13(11): 2432-2447, 2023 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37623743
12.
Small molecule inhibitors of the Pyk2 and FAK kinases modulate chemoattractant-induced migration, adhesion and Akt activation in follicular and marginal zone B cells.
Cell Immunol
; 275(1-2): 47-54, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-22507871
13.
A novel series of glucagon receptor antagonists with reduced molecular weight and lipophilicity.
Bioorg Med Chem Lett
; 22(1): 415-20, 2012 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22119466
14.
Discovery of new piperidine amide triazolobenzodiazepinones as intestinal-selective CCK1 receptor agonists.
Bioorg Med Chem Lett
; 22(8): 2943-7, 2012 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22424974
15.
The design and synthesis of indazole and pyrazolopyridine based glucokinase activators for the treatment of type 2 diabetes mellitus.
Bioorg Med Chem Lett
; 22(23): 7100-5, 2012 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23089526
16.
Identification of novel series of pyrazole and indole-urea based DFG-out PYK2 inhibitors.
Bioorg Med Chem Lett
; 22(24): 7523-9, 2012 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23153798
17.
Exploring aromatic chemical space with NEAT: novel and electronically equivalent aromatic template.
J Chem Inf Model
; 52(5): 1114-23, 2012 May 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-22486394
18.
Design and synthesis of potent, orally-active DGAT-1 inhibitors containing a dioxino[2,3-d]pyrimidine core.
Bioorg Med Chem Lett
; 21(20): 6122-5, 2011 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21908190
19.
Discovery tactics to mitigate toxicity risks due to reactive metabolite formation with 2-(2-hydroxyaryl)-5-(trifluoromethyl)pyrido[4,3-d]pyrimidin-4(3h)-one derivatives, potent calcium-sensing receptor antagonists and clinical candidate(s) for the treatment of osteoporosis.
Chem Res Toxicol
; 23(6): 1115-26, 2010 Jun 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-20507089
20.
Structure-pharmacokinetic relationship of in vivo rat biliary excretion.
Biopharm Drug Dispos
; 31(1): 82-90, 2010 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-19908216