Pesquisa | Portal de Pesquisa da BVS Enfermagem

1.

Increased cathepsin S in Prdm1^-/- dendritic cells alters the T_FH cell repertoire and contributes to lupus.

Kim, Sun Jung; Schätzle, Sebastian; Ahmed, S Sohail; Haap, Wolfgang; Jang, Su Hwa; Gregersen, Peter K; Georgiou, George; Diamond, Betty.

Nat Immunol ; 18(9): 1016-1024, 2017 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-28692065

2.

DOTAM-Based, Targeted, Activatable Fluorescent Probes for the Highly Sensitive and Selective Detection of Cancer Cells.

Brennecke, Benjamin; Wang, Qinghua; Haap, Wolfgang; Grether, Uwe; Hu, Hai-Yu; Nazaré, Marc.

Bioconjug Chem ; 32(4): 702-712, 2021 04 21.

Artigo em Inglês | MEDLINE | ID: mdl-33691062

3.

Cathepsin S Cleavage of Protease-Activated Receptor-2 on Endothelial Cells Promotes Microvascular Diabetes Complications.

Kumar Vr, Santhosh; Darisipudi, Murthy N; Steiger, Stefanie; Devarapu, Satish Kumar; Tato, Maia; Kukarni, Onkar P; Mulay, Shrikant R; Thomasova, Dana; Popper, Bastian; Demleitner, Jana; Zuchtriegel, Gabriele; Reichel, Christoph; Cohen, Clemens D; Lindenmeyer, Maja T; Liapis, Helen; Moll, Solange; Reid, Emma; Stitt, Alan W; Schott, Brigitte; Gruner, Sabine; Haap, Wolfgang; Ebeling, Martin; Hartmann, Guido; Anders, Hans-Joachim.

J Am Soc Nephrol ; 27(6): 1635-49, 2016 06.

Artigo em Inglês | MEDLINE | ID: mdl-26567242

4.

Selective cathepsin S inhibition attenuates atherosclerosis in apolipoprotein E-deficient mice with chronic renal disease.

Figueiredo, Jose-Luiz; Aikawa, Masanori; Zheng, Chunyu; Aaron, Jacob; Lax, Lilian; Libby, Peter; de Lima Filho, Jose Luiz; Gruener, Sabine; Fingerle, Jürgen; Haap, Wolfgang; Hartmann, Guido; Aikawa, Elena.

Am J Pathol ; 185(4): 1156-66, 2015 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-25680278

5.

Cathepsin S inhibition suppresses systemic lupus erythematosus and lupus nephritis because cathepsin S is essential for MHC class II-mediated CD4 T cell and B cell priming.

Rupanagudi, Khader Valli; Kulkarni, Onkar P; Lichtnekert, Julia; Darisipudi, Murthy Narayana; Mulay, Shrikant R; Schott, Brigitte; Gruner, Sabine; Haap, Wolfgang; Hartmann, Guido; Anders, Hans-Joachim.

Ann Rheum Dis ; 74(2): 452-63, 2015 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-24300027

6.

Peptide barcodes meet drug discovery.

Haap, Wolfgang.

Science ; 379(6635): 883, 2023 03 03.

Artigo em Inglês | MEDLINE | ID: mdl-36862768

7.

Drug Discovery Efforts to Identify Novel Treatments for Neglected Tropical Diseases - Cysteine Protease Inhibitors.

Giroud, Maude; Kuhn, Bernd; Haap, Wolfgang.

Curr Med Chem ; 2023 Nov 01.

Artigo em Inglês | MEDLINE | ID: mdl-37916489

8.

Effects of Cathepsin S Inhibition in the Age-Related Dry Eye Phenotype.

Galletti, Jeremias G; Scholand, Kaitlin K; Trujillo-Vargas, Claudia M; Haap, Wolfgang; Santos-Ferreira, Tiago; Ullmer, Christoph; Yu, Zhiyuan; de Paiva, Cintia S.

Invest Ophthalmol Vis Sci ; 64(11): 7, 2023 08 01.

Artigo em Inglês | MEDLINE | ID: mdl-37540176

9.

Molecular recognition at the active site of factor Xa: cation-π interactions, stacking on planar peptide surfaces, and replacement of structural water.

Salonen, Laura M; Holland, Mareike C; Kaib, Philip S J; Haap, Wolfgang; Benz, Jörg; Mary, Jean-Luc; Kuster, Olivier; Schweizer, W Bernd; Banner, David W; Diederich, François.

Chemistry ; 18(1): 213-22, 2012 Jan 02.

Artigo em Inglês | MEDLINE | ID: mdl-22162109

10.

Small-Molecule Lead-Finding Trends across the Roche and Genentech Research Organizations.

Dragovich, Peter S; Haap, Wolfgang; Mulvihill, Melinda M; Plancher, Jean-Marc; Stepan, Antonia F.

J Med Chem ; 65(4): 3606-3615, 2022 02 24.

Artigo em Inglês | MEDLINE | ID: mdl-35138850

11.

Orally active aminopyridines as inhibitors of tetrameric fructose-1,6-bisphosphatase.

Hebeisen, Paul; Haap, Wolfgang; Kuhn, Bernd; Mohr, Peter; Wessel, Hans Peter; Zutter, Ulrich; Kirchner, Stephan; Ruf, Armin; Benz, Jörg; Joseph, Catherine; Alvarez-Sánchez, Rubén; Gubler, Marcel; Schott, Brigitte; Benardeau, Agnes; Tozzo, Effie; Kitas, Eric.

Bioorg Med Chem Lett ; 21(11): 3237-42, 2011 Jun 01.

Artigo em Inglês | MEDLINE | ID: mdl-21550236

12.

What We Learned in 25 Years of Interactive Molecular Design Sessions.

Kuhn, Bernd; Haap, Wolfgang; Obst-Sander, Ulrike; Kramer, Christian; Stahl, Martin.

ChemMedChem ; 16(18): 2760-2763, 2021 09 16.

Artigo em Inglês | MEDLINE | ID: mdl-34374230

13.

Discovery of a factor Xa inhibitor (3R,4R)-1-(2,2-difluoro-ethyl)-pyrrolidine-3,4-dicarboxylic acid 3-[(5-chloro-pyridin-2-yl)-amide] 4-[[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenyl]-amide] as a clinical candidate.

Anselm, Lilli; Banner, David W; Benz, Jörg; Zbinden, Katrin Groebke; Himber, Jacques; Hilpert, Hans; Huber, Walter; Kuhn, Bernd; Mary, Jean-Luc; Otteneder, Michael B; Panday, Narendra; Ricklin, Fabienne; Stahl, Martin; Thomi, Stefan; Haap, Wolfgang.

Bioorg Med Chem Lett ; 20(17): 5313-9, 2010 Sep 01.

Artigo em Inglês | MEDLINE | ID: mdl-20650636

14.

Sulfonylureido thiazoles as fructose-1,6-bisphosphatase inhibitors for the treatment of type-2 diabetes.

Kitas, Eric; Mohr, Peter; Kuhn, Bernd; Hebeisen, Paul; Wessel, Hans Peter; Haap, Wolfgang; Ruf, Armin; Benz, Jörg; Joseph, Catherine; Huber, Walter; Sanchez, Ruben Alvarez; Paehler, Axel; Benardeau, Agnes; Gubler, Marcel; Schott, Brigitte; Tozzo, Effie.

Bioorg Med Chem Lett ; 20(2): 594-9, 2010 Jan 15.

Artigo em Inglês | MEDLINE | ID: mdl-19969452

15.

2 H-1,2,3-Triazole-Based Dipeptidyl Nitriles: Potent, Selective, and Trypanocidal Rhodesain Inhibitors by Structure-Based Design.

Giroud, Maude; Kuhn, Bernd; Saint-Auret, Sarah; Kuratli, Christoph; Martin, Rainer E; Schuler, Franz; Diederich, François; Kaiser, Marcel; Brun, Reto; Schirmeister, Tanja; Haap, Wolfgang.

J Med Chem ; 61(8): 3370-3388, 2018 04 26.

Artigo em Inglês | MEDLINE | ID: mdl-29590751

16.

Repurposing a Library of Human Cathepsin L Ligands: Identification of Macrocyclic Lactams as Potent Rhodesain and Trypanosoma brucei Inhibitors.

Giroud, Maude; Dietzel, Uwe; Anselm, Lilli; Banner, David; Kuglstatter, Andreas; Benz, Jörg; Blanc, Jean-Baptiste; Gaufreteau, Delphine; Liu, Haixia; Lin, Xianfeng; Stich, August; Kuhn, Bernd; Schuler, Franz; Kaiser, Marcel; Brun, Reto; Schirmeister, Tanja; Kisker, Caroline; Diederich, François; Haap, Wolfgang.

J Med Chem ; 61(8): 3350-3369, 2018 04 26.

Artigo em Inglês | MEDLINE | ID: mdl-29590750

17.

Cathepsin S inhibition suppresses autoimmune-triggered inflammatory responses in macrophages.

Thanei, Sophia; Theron, Michel; Silva, Ana Patricia; Reis, Bernhard; Branco, Leonore; Schirmbeck, Lucia; Kolb, Fabrice A; Haap, Wolfgang; Schindler, Thomas; Trendelenburg, Marten.

Biochem Pharmacol ; 146: 151-164, 2017 12 15.

Artigo em Inglês | MEDLINE | ID: mdl-28987592

18.

Inhibition of the Cysteine Protease Human CathepsinâL by Triazine Nitriles: AmideâââHeteroarene π-Stacking Interactions and Chalcogen Bonding in the S3 Pocket.

Giroud, Maude; Ivkovic, Jakov; Martignoni, Mara; Fleuti, Marianne; Trapp, Nils; Haap, Wolfgang; Kuglstatter, Andreas; Benz, Jörg; Kuhn, Bernd; Schirmeister, Tanja; Diederich, François.

ChemMedChem ; 12(3): 257-270, 2017 02 03.

Artigo em Inglês | MEDLINE | ID: mdl-27992115

19.

Cathepsin S inhibition combines control of systemic and peripheral pathomechanisms of autoimmune tissue injury.

Tato, Maia; Kumar, Santhosh V; Liu, Yajuan; Mulay, Shrikant R; Moll, Solange; Popper, Bastian; Eberhard, Jonathan N; Thomasova, Dana; Rufer, Arne Christian; Gruner, Sabine; Haap, Wolfgang; Hartmann, Guido; Anders, Hans-Joachim.

Sci Rep ; 7(1): 2775, 2017 06 05.

Artigo em Inglês | MEDLINE | ID: mdl-28584258

20.

Systematic investigation of halogen bonding in protein-ligand interactions.

Hardegger, Leo A; Kuhn, Bernd; Spinnler, Beat; Anselm, Lilli; Ecabert, Robert; Stihle, Martine; Gsell, Bernard; Thoma, Ralf; Diez, Joachim; Benz, Jörg; Plancher, Jean-Marc; Hartmann, Guido; Banner, David W; Haap, Wolfgang; Diederich, François.

Angew Chem Int Ed Engl ; 50(1): 314-8, 2011 Jan 03.

Artigo em Inglês | MEDLINE | ID: mdl-21184410

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