Detalhe da pesquisa
1.
Insights into activity and inhibition from the crystal structure of human O-GlcNAcase.
Nat Chem Biol
; 13(6): 613-615, 2017 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-28346407
2.
Structure and Function of the Hypertension Variant A486V of G Protein-coupled Receptor Kinase 4.
J Biol Chem
; 290(33): 20360-73, 2015 Aug 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-26134571
3.
Structural basis for selective small molecule kinase inhibition of activated c-Met.
J Biol Chem
; 286(13): 11218-25, 2011 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21247903
4.
Structural basis of human p70 ribosomal S6 kinase-1 regulation by activation loop phosphorylation.
J Biol Chem
; 285(7): 4587-94, 2010 Feb 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-19864428
5.
Structures of active-state orexin receptor 2 rationalize peptide and small-molecule agonist recognition and receptor activation.
Nat Commun
; 12(1): 815, 2021 02 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33547286
6.
Structural definition and substrate specificity of the S28 protease family: the crystal structure of human prolylcarboxypeptidase.
BMC Struct Biol
; 10: 16, 2010 Jun 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-20540760
7.
Expression, purification and crystallization of human prolylcarboxypeptidase.
Acta Crystallogr Sect F Struct Biol Cryst Commun
; 66(Pt 6): 702-5, 2010 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20516604
8.
Structural basis for the cooperative allosteric activation of the free fatty acid receptor GPR40.
Nat Struct Mol Biol
; 24(7): 570-577, 2017 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-28581512
9.
Integration of Affinity Selection-Mass Spectrometry and Functional Cell-Based Assays to Rapidly Triage Druggable Target Space within the NF-κB Pathway.
J Biomol Screen
; 21(6): 608-19, 2016 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-26969322
10.
Protein expression plasmids produced rapidly: streamlining cloning protocols and robotic handling.
Assay Drug Dev Technol
; 3(6): 661-74, 2005 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-16438661
11.
Synthesis and Evaluation of Heterocyclic Catechol Mimics as Inhibitors of Catechol-O-methyltransferase (COMT).
ACS Med Chem Lett
; 6(3): 318-23, 2015 Mar 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-25815153
12.
Characterization of non-nitrocatechol pan and isoform specific catechol-O-methyltransferase inhibitors and substrates.
ACS Chem Neurosci
; 3(2): 129-40, 2012 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22860182
13.
Structure of human prostasin, a target for the regulation of hypertension.
J Biol Chem
; 283(50): 34864-72, 2008 Dec 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-18922802
14.
Biochemical and structural characterization of a novel class of inhibitors of the type 1 insulin-like growth factor and insulin receptor kinases.
Biochemistry
; 44(27): 9430-40, 2005 Jul 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-15996097
15.
Structure of apo, unactivated insulin-like growth factor-1 receptor kinase at 1.5 A resolution.
Acta Crystallogr D Biol Crystallogr
; 59(Pt 10): 1725-30, 2003 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-14501110
16.
Crystal structure of the Apo, unactivated insulin-like growth factor-1 receptor kinase. Implication for inhibitor specificity.
J Biol Chem
; 277(41): 38797-802, 2002 Oct 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-12138114