Detalhe da pesquisa
1.
N4BP1 coordinates ubiquitin-dependent crosstalk within the IκB kinase family to limit Toll-like receptor signaling and inflammation.
Immunity
; 57(5): 973-986.e7, 2024 May 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38697117
2.
MAP4K4 regulates integrin-FERM binding to control endothelial cell motility.
Nature
; 519(7544): 425-30, 2015 Mar 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-25799996
3.
Identification of Noncompetitive Protein-Ligand Interactions for Structural Optimization.
J Chem Inf Model
; 60(12): 6595-6611, 2020 12 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-33085891
4.
Quantitative Determination of Protein-Ligand Affinity by Size Exclusion Chromatography Directly Coupled to High-Resolution Native Mass Spectrometry.
Anal Chem
; 91(1): 903-911, 2019 01 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30481450
5.
Deep Sequencing-guided Design of a High Affinity Dual Specificity Antibody to Target Two Angiogenic Factors in Neovascular Age-related Macular Degeneration.
J Biol Chem
; 290(36): 21773-86, 2015 Sep 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-26088137
6.
Fragment-based identification and optimization of a class of potent pyrrolo[2,1-f][1,2,4]triazine MAP4K4 inhibitors.
Bioorg Med Chem Lett
; 24(18): 4546-4552, 2014 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25139565
7.
Potent and selective binders of the E3 ubiquitin ligase ZNRF3 stimulate Wnt signaling and intestinal organoid growth.
Cell Chem Biol
; 2023 Dec 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-38056465
8.
Nanolitre-scale crystallization using acoustic liquid-transfer technology.
Acta Crystallogr D Biol Crystallogr
; 68(Pt 8): 893-900, 2012 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-22868754
9.
Chemical space docking enables large-scale structure-based virtual screening to discover ROCK1 kinase inhibitors.
Nat Commun
; 13(1): 6447, 2022 10 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-36307407
10.
Antibody interfaces revealed through structural mining.
Comput Struct Biotechnol J
; 20: 4952-4968, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36147680
11.
Acoustic matrix microseeding: improving protein crystal growth with minimal chemical bias.
Acta Crystallogr D Biol Crystallogr
; 66(Pt 5): 568-76, 2010 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-20445232
12.
Discovery of piperidin-4-yl-aminopyrimidines as HIV-1 reverse transcriptase inhibitors. N-benzyl derivatives with broad potency against resistant mutant viruses.
Bioorg Med Chem Lett
; 20(14): 4215-8, 2010 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20538456
13.
Cyclic amide bioisosterism: strategic application to the design and synthesis of HCV NS5B polymerase inhibitors.
Bioorg Med Chem Lett
; 20(15): 4614-9, 2010 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20584604
14.
Exploration of piperidine-4-yl-aminopyrimidines as HIV-1 reverse transcriptase inhibitors. N-Phenyl derivatives with broad potency against resistant mutant viruses.
Bioorg Med Chem Lett
; 20(20): 6020-3, 2010 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20829038
15.
Implementation of the CYP Index for the Design of Selective Tryptophan-2,3-dioxygenase Inhibitors.
ACS Med Chem Lett
; 11(4): 541-549, 2020 Apr 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32292562
16.
Non-nucleoside inhibitors of HCV polymerase NS5B. Part 4: structure-based design, synthesis, and biological evaluation of benzo[d]isothiazole-1,1-dioxides.
Bioorg Med Chem Lett
; 19(19): 5652-6, 2009 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19709881
17.
Non-nucleoside inhibitors of HCV polymerase NS5B. Part 2: Synthesis and structure-activity relationships of benzothiazine-substituted quinolinediones.
Bioorg Med Chem Lett
; 19(13): 3642-6, 2009 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19457662
18.
Non-nucleoside inhibitors of HCV polymerase NS5B. Part 3: synthesis and optimization studies of benzothiazine-substituted tetramic acids.
Bioorg Med Chem Lett
; 19(19): 5648-51, 2009 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19700319
19.
Structure Based Design of Potent Selective Inhibitors of Protein Kinase D1 (PKD1).
ACS Med Chem Lett
; 10(9): 1260-1265, 2019 Sep 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31531194
20.
Discovery of Clinical Candidate (1R,4r)-4-((R)-2-((S)-6-Fluoro-5H-imidazo[5,1-a]isoindol-5-yl)-1-hydroxyethyl)cyclohexan-1-ol (Navoximod), a Potent and Selective Inhibitor of Indoleamine 2,3-Dioxygenase 1.
J Med Chem
; 62(14): 6705-6733, 2019 07 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-31264862