Detalhe da pesquisa
1.
Therapeutic Ligands Antagonize Estrogen Receptor Function by Impairing Its Mobility.
Cell
; 178(4): 949-963.e18, 2019 08 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31353221
2.
Discovery of GNE-502 as an orally bioavailable and potent degrader for estrogen receptor positive breast cancer.
Bioorg Med Chem Lett
; 50: 128335, 2021 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34425201
3.
Antibody-mediated delivery of chimeric protein degraders which target estrogen receptor alpha (ERα).
Bioorg Med Chem Lett
; 30(4): 126907, 2020 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31902710
4.
Discovery of a C-8 hydroxychromene as a potent degrader of estrogen receptor alpha with improved rat oral exposure over GDC-0927.
Bioorg Med Chem Lett
; 29(16): 2090-2093, 2019 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31311734
5.
Conjugation of Indoles to Antibodies through a Novel Self-Immolating Linker.
Chemistry
; 24(19): 4830-4834, 2018 Apr 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-29493023
6.
Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 1: Exploration of Antibody Linker, Payload Loading, and Payload Molecular Properties.
J Med Chem
; 64(5): 2534-2575, 2021 03 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33596065
7.
GDC-9545 (Giredestrant): A Potent and Orally Bioavailable Selective Estrogen Receptor Antagonist and Degrader with an Exceptional Preclinical Profile for ER+ Breast Cancer.
J Med Chem
; 64(16): 11841-11856, 2021 08 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-34251202
8.
Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 2: Improvement of In Vitro Antiproliferation Activity and In Vivo Antitumor Efficacy.
J Med Chem
; 64(5): 2576-2607, 2021 03 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33596073
9.
Structures of Arg- and Gln-type bacterial cysteine dioxygenase homologs.
Protein Sci
; 24(1): 154-61, 2015 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-25307852