Detalhe da pesquisa
1.
Assessment of KRAS G12C Target Engagement by a Covalent Inhibitor in Tumor Biopsies Using an Ultra-Sensitive Immunoaffinity 2D-LC-MS/MS Approach.
Anal Chem
; 94(37): 12927-12933, 2022 09 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-36083155
2.
Automated, Generic Reagent and Ultratargeted 2D-LC-MS/MS Enabling Quantification of Biotherapeutics and Soluble Targets down to pg/mL Range in Serum.
Anal Chem
; 92(13): 9412-9420, 2020 07 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32510921
3.
Antibody-mediated delivery of chimeric protein degraders which target estrogen receptor alpha (ERα).
Bioorg Med Chem Lett
; 30(4): 126907, 2020 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31902710
4.
Antibody-Drug Conjugates Derived from Cytotoxic seco-CBI-Dimer Payloads Are Highly Efficacious in Xenograft Models and Form Protein Adducts In Vivo.
Bioconjug Chem
; 30(5): 1356-1370, 2019 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30966735
5.
Modulating Antibody-Drug Conjugate Payload Metabolism by Conjugation Site and Linker Modification.
Bioconjug Chem
; 29(4): 1155-1167, 2018 04 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-29481745
6.
Conjugation of Indoles to Antibodies through a Novel Self-Immolating Linker.
Chemistry
; 24(19): 4830-4834, 2018 Apr 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-29493023
7.
High-Resolution Accurate-Mass Mass Spectrometry Enabling In-Depth Characterization of in Vivo Biotransformations for Intact Antibody-Drug Conjugates.
Anal Chem
; 89(10): 5476-5483, 2017 05 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-28429938
8.
Quantification of mutant SPOP proteins in prostate cancer using mass spectrometry-based targeted proteomics.
J Transl Med
; 15(1): 175, 2017 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28810879
9.
Attachment Site Cysteine Thiol pKa Is a Key Driver for Site-Dependent Stability of THIOMAB Antibody-Drug Conjugates.
Bioconjug Chem
; 28(10): 2538-2548, 2017 10 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-28885827
10.
Development of Efficient Chemistry to Generate Site-Specific Disulfide-Linked Protein- and Peptide-Payload Conjugates: Application to THIOMAB Antibody-Drug Conjugates.
Bioconjug Chem
; 28(8): 2086-2098, 2017 08 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-28636382
11.
Mining the human urine proteome for monitoring renal transplant injury.
Kidney Int
; 89(6): 1244-52, 2016 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-27165815
12.
Chemical Structure and Concentration of Intratumor Catabolites Determine Efficacy of Antibody Drug Conjugates.
Drug Metab Dispos
; 44(9): 1517-23, 2016 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27417182
13.
The identification of novel potential injury mechanisms and candidate biomarkers in renal allograft rejection by quantitative proteomics.
Mol Cell Proteomics
; 13(2): 621-31, 2014 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-24335474
14.
Sensitive targeted quantification of ERK phosphorylation dynamics and stoichiometry in human cells without affinity enrichment.
Anal Chem
; 87(2): 1103-10, 2015 Jan 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-25517423
15.
Analytical platform evaluation for quantification of ERG in prostate cancer using protein and mRNA detection methods.
J Transl Med
; 13: 54, 2015 Feb 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-25889691
16.
Expediting SRM assay development for large-scale targeted proteomics experiments.
J Proteome Res
; 13(10): 4479-87, 2014 Oct 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-25145539
17.
CD90 is identified as a candidate marker for cancer stem cells in primary high-grade gliomas using tissue microarrays.
Mol Cell Proteomics
; 11(6): M111.010744, 2012 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-22203689
18.
Targeted quantification of low ng/mL level proteins in human serum without immunoaffinity depletion.
J Proteome Res
; 12(7): 3353-61, 2013 Jul 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-23763644
19.
Long-gradient separations coupled with selected reaction monitoring for highly sensitive, large scale targeted protein quantification in a single analysis.
Anal Chem
; 85(19): 9196-203, 2013 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24004026
20.
Immunohistochemical staining, laser capture microdissection, and filter-aided sample preparation-assisted proteomic analysis of target cell populations within tissue samples.
Electrophoresis
; 34(11): 1627-36, 2013 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-23436586