Detalhe da pesquisa
1.
Hydroxynorketamines: Pharmacology and Potential Therapeutic Applications.
Pharmacol Rev
; 73(2): 763-791, 2021 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33674359
2.
(2R,6R)-hydroxynorketamine exerts mGlu2 receptor-dependent antidepressant actions.
Proc Natl Acad Sci U S A
; 116(13): 6441-6450, 2019 03 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-30867285
3.
Ketamine and Ketamine Metabolite Pharmacology: Insights into Therapeutic Mechanisms.
Pharmacol Rev
; 70(3): 621-660, 2018 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29945898
4.
Sex-dependent metabolism of ketamine and (2R,6R)-hydroxynorketamine in mice and humans.
J Psychopharmacol
; 36(2): 170-182, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34971525
5.
Hydroxynorketamine Pharmacokinetics and Antidepressant Behavioral Effects of (2,6)- and (5R)-Methyl-(2R,6R)-hydroxynorketamines.
ACS Chem Neurosci
; 13(4): 510-523, 2022 02 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-35113535
6.
Experimenters' sex modulates mouse behaviors and neural responses to ketamine via corticotropin releasing factor.
Nat Neurosci
; 25(9): 1191-1200, 2022 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36042309
7.
Group II metabotropic glutamate receptor blockade promotes stress resilience in mice.
Neuropsychopharmacology
; 44(10): 1788-1796, 2019 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30939596
8.
(R)-Ketamine exerts antidepressant actions partly via conversion to (2R,6R)-hydroxynorketamine, while causing adverse effects at sub-anaesthetic doses.
Br J Pharmacol
; 176(14): 2573-2592, 2019 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-30941749
9.
Mouse, rat, and dog bioavailability and mouse oral antidepressant efficacy of (2R,6R)-hydroxynorketamine.
J Psychopharmacol
; 33(1): 12-24, 2019 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30488740
10.
A Negative Allosteric Modulator for α5 Subunit-Containing GABA Receptors Exerts a Rapid and Persistent Antidepressant-Like Action without the Side Effects of the NMDA Receptor Antagonist Ketamine in Mice.
eNeuro
; 4(1)2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28275719